#NEXUS begin taxa; dimensions ntax=85; taxlabels CteWnt1 CteWnt10 CteWnt11 CteWnt16 CteWnt2 CteWnt4 CteWnt5 CteWnt6 CteWnt7 CteWnt8 CteWnt9 CteWntA EgrWnt1 EgrWnt11a EgrWnt11b 'EgrWnt2/10' EgrWnt4 EgrWnt5 'EmuWnt1.ORF' 'EmuWnt11.1' 'EmuWnt11.2' 'EmuWnt2/5/8/10.ORF' EmuWnt4 EmuWnt5 HmiWnt1 HmiWnt11a HmiWnt11b HmiWnt2 HmiWnt4 HmiWnt5 HroWnt1 HroWnt10 HroWnt11a HroWnt11b HroWnt11C HroWnt16a HroWnt16b HroWnt2 HroWnt4 HroWnt5a HroWnt5b HroWnt6 HroWnt7 LgiWnt1 LgiWnt10 LgiWnt11 LgiWnt16 LgiWnt2 LgiWnt4 LgiWnt5 LgiWnt6 LgiWnt7 LgiWnt9 LgiWntA PduWnt1 PduWnt10 PduWnt11 PduWnt16 PduWnt2 PduWnt4 PduWnt5 PduWnt6 'PduWnt7 - wnt7 CDS' PduWnt8 'PduWnt9/14/15' PduWntA PvuWnt1 PvuWnt10 PvuWnt2 PvuWntA SmaWnt1 SmaWnt11 SmaWnt11b 'SmaWnt2(d)' 'SmaWnt4(d)' SmaWnt5 SmeWnt1 SmeWnt11a SmeWnt11b SmeWnt2b SmeWnt4 'SmeWnt4.' 'SmeWnt4..' SmeWnt5 SmeWntP-4 ; end; begin characters; dimensions nchar=970; format datatype=protein missing=? gap=- interleave=yes; matrix CteWnt1 ------------------------------------------------------------ CteWnt10 ------------------------------------------------------------ CteWnt11 ------------------------------------------------------------ CteWnt16 ------------------------------------------------------------ CteWnt2 ------------------------------------------------------------ CteWnt4 ------------------------------------------------------------ CteWnt5 ------------------------------------------------------------ CteWnt6 ------------------------------------------------------------ CteWnt7 ------------------------------------------------------------ CteWnt8 ------------------------------------------------------------ CteWnt9 ------------------------------------------------------------ CteWntA ------------------------------------------------------------ EgrWnt1 ------------------------------------------------------------ EgrWnt11a ------------------------------------------------------------ EgrWnt11b ------------------------------------------------------------ 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ------------------------------------------------------------ EgrWnt5 ------------------------------------------------------------ 'EmuWnt1.ORF' ------------------------------------------------------------ 'EmuWnt11.1' ------------------------------------------------------------ 'EmuWnt11.2' ------------------------------------------------------------ 'EmuWnt2/5/8/10.ORF' ------------------------------------------------------------ EmuWnt4 ------------------------------------------------------------ EmuWnt5 ------------------------------------------------------------ HmiWnt1 ------------------------------------------------------------ HmiWnt11a ------------------------------------------------------------ HmiWnt11b ------------------------------------------------------------ HmiWnt2 ------------------------------------------------------------ HmiWnt4 ------------------------------------------------------------ HmiWnt5 ------------------------------------------------------------ HroWnt1 ------------------------------------------------------------ HroWnt10 ------------------------------------------------------------ HroWnt11a ------------------------------------------------------------ HroWnt11b ------------------------------------------------------------ HroWnt11C ------------------------------------------------------------ HroWnt16a ------------------------------------------------------------ HroWnt16b ------------------------------------------------------------ HroWnt2 ------------------------------------------------------------ HroWnt4 ------------------------------------------------------------ HroWnt5a ------------------------------------------------------------ HroWnt5b ------------------------------------------------------------ HroWnt6 ------------------------------------------------------------ HroWnt7 ------------------------------------------------------------ LgiWnt1 ------------------------------------------------------------ LgiWnt10 ------------------------------------------------------------ LgiWnt11 ------------------------------------------------------------ LgiWnt16 ------------------------------------------------------------ LgiWnt2 ------------------------------------------------------------ LgiWnt4 ------------------------------------------------------------ LgiWnt5 ------------------------------------------------------------ LgiWnt6 ------------------------------------------------------------ LgiWnt7 ------------------------------------------------------------ LgiWnt9 ------------------------------------------------------------ LgiWntA ------------------------------------------------------------ PduWnt1 ------------------------------------------------------------ PduWnt10 ------------------------------------------------------------ PduWnt11 ------------------------------------------------------------ PduWnt16 ------------------------------------------------------------ PduWnt2 ------------------------------------------------------------ PduWnt4 ------------------------------------------------------------ PduWnt5 ------------------------------------------------------------ PduWnt6 ------------------------------------------------------------ 'PduWnt7 - wnt7 CDS' ------------------------------------------------------------ PduWnt8 ------------------------------------------------------------ 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA ------------------------------------------------------------ PvuWnt1 ------------------------------------------------------------ PvuWnt10 ------------------------------------------------------------ PvuWnt2 ------------------------------------------------------------ PvuWntA ------------------------------------------------------------ SmaWnt1 ------------------------------------------------------------ SmaWnt11 ------------------------------------------------------------ SmaWnt11b ------------------------------------------------------------ 'SmaWnt2(d)' ------------------------------------------------------------ 'SmaWnt4(d)' MSVWLNILLFLCLFTLSSQLRELLITDIPDDNLQPDSLSQSPENNNIKQKHDAIVGDSTF SmaWnt5 ------------------------------------------------------------ SmeWnt1 ------------------------------------------------------------ SmeWnt11a ------------------------------------------------------------ SmeWnt11b ------------------------------------------------------------ SmeWnt2b ------------------------------------------------------------ SmeWnt4 ------------------------------------------------------------ 'SmeWnt4.' ------------------------------------------------------------ 'SmeWnt4..' ------------------------------------------------------------ SmeWnt5 ------------------------------------------------------------ SmeWntP-4 ------------------------------------------------------------ CteWnt1 ---------------------------------MNLYMFQMLVIFVGMATLEVVTPGKGG CteWnt10 ------------------------------------------------------------ CteWnt11 ------------------------------------------------------------ CteWnt16 -----------------------------------MMATGSRRRGSNPREWSLAALWLGA CteWnt2 ------------------------------------------------------------ CteWnt4 ---------------------------------------------------MKALDFCLI CteWnt5 ------------------------------------------------------------ CteWnt6 -------------------------------------------------------MKSEG CteWnt7 ----------------------------------------------------MILRKILP CteWnt8 ------------------------------------------------------------ CteWnt9 ------------------------------------------------------------ CteWntA ------------------------------------------------------------ EgrWnt1 ------------------------------------------------------------ EgrWnt11a ------------------------------------------------------------ EgrWnt11b ------------------------------------------------------------ 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ------------------------------------------------------------ EgrWnt5 ------------------------------------------------------------ 'EmuWnt1.ORF' ------------------------------------------------------------ 'EmuWnt11.1' ------------------------------------------------------------ 'EmuWnt11.2' ------------------------------------------------------------ 'EmuWnt2/5/8/10.ORF' ------------------------------------------------------------ EmuWnt4 ------------------------------------------------------------ EmuWnt5 ------------------------------------------------------------ HmiWnt1 ------------------------------------------------------------ HmiWnt11a -------------------------------MLWTISLPFRGSLGVLLSLLILLLICRET HmiWnt11b ------------------------------KKSGSTNMQVPPRKCSTWIVWIALLLCLLQ HmiWnt2 ------------------------------------------------------------ HmiWnt4 ------------------------------------------------------------ HmiWnt5 ------------------------------------------------------------ HroWnt1 ------------------------------------------------------------ HroWnt10 ------------------------------------------------------------ HroWnt11a ------------------------------------------------------------ HroWnt11b ------------------------------------------------------------ HroWnt11C ------------------------------------------------------------ HroWnt16a ------------------------------------------------------------ HroWnt16b ------------------------------------------------------------ HroWnt2 ------------------------------------------------------------ HroWnt4 ------------------------------------------------------------ HroWnt5a ------------------------------------------------------------ HroWnt5b ------------------------------------------------------------ HroWnt6 ------------------------------------------------------------ HroWnt7 ------------------REMKITPKDHTLKIYLNCKFHSVLTNKHDKSSSNPPIKIPSY LgiWnt1 ------------------------------------------------------------ LgiWnt10 ------------------------------------------------------------ LgiWnt11 ------------------------------------------------------------ LgiWnt16 ------------------------------------------------------------ LgiWnt2 ------------------------------------------------------------ LgiWnt4 ------------------------------------------------------------ LgiWnt5 ------------------------------------------------------------ LgiWnt6 -------------------------------------------------------MRVQG LgiWnt7 ------------------------------------------------------------ LgiWnt9 ------------------------------------------------------MSAATG LgiWntA ------------------------------------------------------------ PduWnt1 ------------------------------------------------------------ PduWnt10 ------------------------------------------------------------ PduWnt11 ------------------------------------------------RGVAGSLLPGLL PduWnt16 ------------------------------------------------------------ PduWnt2 ------------------------------------------------------------ PduWnt4 ------------------------------TRRKVGFTLNRNCQHFRHFTMTKICAAVLI PduWnt5 ------------------------------------------------------------ PduWnt6 -----------------------------------------------------MRKESVT 'PduWnt7 - wnt7 CDS' ------------------------------------------------------------ PduWnt8 ------------------------------------------------------------ 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA ------------------------------------------------------------ PvuWnt1 ------------------------------------------------------------ PvuWnt10 ------------------------------------------------------------ PvuWnt2 ------------------------------------------------------------ PvuWntA ------------------------------------------------------------ SmaWnt1 ------------------------------------------------------------ SmaWnt11 ------------------------------------------------------------ SmaWnt11b --------------------------------------------------MATDIKLDFF 'SmaWnt2(d)' MLSHLKKLNSPLYMPVKHINHITNPFEHHHLMNPSNVLNSSGRKLIRASTSSESQDHLLS 'SmaWnt4(d)' VNGLDKNNHNTEVYHRQTNSDLRFIEATKSQSLNYPQTNRNYMNPDLNTDNYNHQRLNQT SmaWnt5 ---MNSTFKSSLLTKGIIIPSIMPLMKNYRSSQYHKGKQYSFNGIFVLILLIYILTLNHI SmeWnt1 ---------MNHSGASICLPLIIKIFLISFSFCLTLSINRNWNNQIFVNHLRNTRWWHLY SmeWnt11a -------------------------------------------MRIFPDLIGNLLMFVIL SmeWnt11b ---------------------------------------MIHFCKLSRVWIYFVIILSFL SmeWnt2b --------------------------------------------MLKISIRILVIFLHLV SmeWnt4 -----------------------------------------------MFLKILVTVLLVI 'SmeWnt4.' ------------------------------MLNWICFYINKSGSMLTLLIVMTIHCKICI 'SmeWnt4..' ---------------------MILCHTNMIIQSMLVLILRFIAETYSSGLVFSMYQLQQI SmeWnt5 ------------------------------------------------------------ SmeWntP-4 ------------------------------------------------MISKIIIFIFMI CteWnt1 GKRSRTRGVKWWNLAHTQHFMSDSLLNPETPLFINPSLQPLTRKQRRLVTRNPG--TSIA CteWnt10 -----------------------PNPALDTSSVCRTIPDLTG-PQYALCLKHPD--VMEV CteWnt11 ---------------MSGLRTASEHWNRTADCVKAKEHGLVK-QQIQICKRNME--LMPV CteWnt16 AIGLLSQGPVGASATWMYLGIAHLGSATTSTHSCHILPGLVY-QQLRVCEENPH--TMPC CteWnt2 ---------------------------VGSGVICDNIPGLMS-RQRLLCRQHPD--VMMS CteWnt4 LLLLEELCGSTSGLRWLALATVGSVDHIQKEEACDTLSGLVK-RQKKICKRNIE--VMHA CteWnt5 ---------------------------------------------------------MPA CteWnt6 AWVCLVFYLICPANIIGLWWAVGSPLVMDPNIICRKSRKLGG-KQHEMCRNEPE--IVEE CteWnt7 PTHAVVVYLYFFVFFTFHRALSSVVALSYAHAICNRIPGLAP-RQRTICLSHPD--SMAA CteWnt8 --------------------------------------SLNN-FLKAGSKSYMA--LVDS CteWnt9 -------------------------MTYNQAQQICLRLKLHP-AQKKMCLSSLG--ISST CteWntA ------------------------------------------------------------ EgrWnt1 ------------------------------------------------------------ EgrWnt11a ----------------YPRDSSAPAFTTRECEIARYHLGFRP-RQARFCNHPRLGFAMLP EgrWnt11b ----------GLHRYPRTKALEKERFTPNECVYAKYRYGLGR-KQLKFCHHPEGSFAMHA 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ------------------------------------------------------------ EgrWnt5 ------------------------------------------------------------ 'EmuWnt1.ORF' ------------------------------------------------------------ 'EmuWnt11.1' ----------------YPRDSSAPAFTTRECEIARYHLGFRP-RQARFCNHPRLGFAMLP 'EmuWnt11.2' ----------GLHRYPRTKALEKERFTPNECAYAKYRYGLGR-KQLKFCHHPEGSFAMHA 'EmuWnt2/5/8/10.ORF' ------------------------------------------------------------ EmuWnt4 ------------------------------------------------------------ EmuWnt5 ------------------------------------------------------------ HmiWnt1 ------------------------------------------------------------ HmiWnt11a GGIQWLGIYHLRKSSDYPRDSTAPAFTARECEIAANHLGFRS-RQRRFCNHPRLGYAMLP HmiWnt11b VEFTQSISWLGLHRYPRSKVLEKERFTPNECFYAKYRYGLGK-KQLEFCHHPEGSFAMHA HmiWnt2 ------------------------------------------------------------ HmiWnt4 ------------------------------------------------------------ HmiWnt5 ----------------------------------MQSYGLSR-SQLVMCHQNFD--HMPI HroWnt1 ------------------------------------------------------------ HroWnt10 ------------------------------------------------------------ HroWnt11a -------------------------------CNRRRTVGLTS-DQKDMCQKNLD--LMTS HroWnt11b -------------------------------ITCPKSEKFLAKQQQEFCRQTQQ--HAHL HroWnt11C ------------------------------------------------------------ HroWnt16a ------------------------------------------------------------ HroWnt16b ------------------------------------------------------------ HroWnt2 ----HRLSSWWTFSRIATKSFDDREYDAYRLCYRHQQPYLSK-KQRETCYTRLD--LMRA HroWnt4 ------------------------------------------------------------ HroWnt5a ------------------------------------------------------------ HroWnt5b ------------------------------------------------------------ HroWnt6 ------------------------------------------------------------ HroWnt7 QLHTTSLVLILSQLFLISSVHCSGVYSLDASVVCNKVPGLVP-EQRRLCRAYAE--AMAV LgiWnt1 -----------------MGHRTNDLRTSVTQLYNNPSLLPLTKKQKKLVTRNPG--SIMA LgiWnt10 ------------------------------------------------------------ LgiWnt11 -----------------------KHKTWENPKMCSKALGLLP-RQRRICKQHLE--IMST LgiWnt16 ------------------------------------IPGLVI-QQKEVCQKNPE--SVYC LgiWnt2 --------------------------------------GLVG-KQRKMCRHYPD--VMVW LgiWnt4 ------------------LAKMTSLGSITDENHCDSLYGFVK-RQKKLCRKNLE--IMDN LgiWnt5 ----------NLGVHHFDTIRKNNLYMLAAQPMCTELQGLSP-GQIRFCRVYHD--HMPS LgiWnt6 VLIGLYFYLIFPANIIGLWWAVGSPLVMDTNSICRKTRRLAG-KQRAICRKEPE--IVEE LgiWnt7 ------MTVSPTVVWAAFSMALSSVVALGANIICNKIPGMAP-KQRAICRSRPD--AIVS LgiWnt9 YFGLTNREPLLSLTWGYHNTALERNKHKYSSAKLCEMLKLHR-RQKRMCRRGKG--IAES LgiWntA ------------------------------------------------------------ PduWnt1 -------EFGTSRNLAYSISLRDNMLNEVAPIYINPSLQPLTRKQRRVVTRNPG--TIVA PduWnt10 ------------------------------------------------------------ PduWnt11 ILIIGLQGCAAIKWLALAKTHEKVWNNTKLCQTLKRDAGLTK-QQVRMCKQNLE--LMGI PduWnt16 ------------------------------------------------------------ PduWnt2 ------------------------------------------------------------ PduWnt4 FFTLELLWNQASGIKWLALARMSSVATIKEDKECNVLDGLVK-KQKKICKKHVE--MMGA PduWnt5 ------------------------------------------------------------ PduWnt6 SIIFCSLLLSCPLRIIGFWWALGSPLAMDPNNICRKSRRFNNPRHRQICRYEPD--VIRQ 'PduWnt7 - wnt7 CDS' ---------RGGVECLVLVYEDCCRHVLGANLICNKVPGLTP-RQRTICRSRPD--AIAA PduWnt8 ------------------------------------------MNNFLMSGPKAYMSFAES 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA ------------------------------------------------------------ PvuWnt1 ------------------------MRLLLYCFLISLCYLLIGAKKGRHRGRMKG------ PvuWnt10 ------------------------------------------------------------ PvuWnt2 ------------------------------------------------------------ PvuWntA ------------------------------------------------------------ SmaWnt1 ------------------------------------------------------------ SmaWnt11 ------------------------------------------------------------ SmaWnt11b LDTISKGIYRLPKSADHPVDSTADRFTPDECQKAANKLGLRR-RQARFCMHPRFGYAMLA 'SmaWnt2(d)' NQNELNQLDNHSQVPIQSFPSNDIDLSNHEISICHTLSGLTN-RQRYICLQHTG--LIWA 'SmaWnt4(d)' QLEQTIQDMNDNNDNMMTTETFVGPDGKLQMSICDHPNGFLR-RQKKLCRQYLH--LMES SmaWnt5 NAFGNMGYWWNLGLLSWRTIHQSPAFLLAPKPLCLRVQGLTH-SQAQLCQRYFD--HMPV SmeWnt1 KMKSDPNIATNSLQYAFTRHQWNQFYSFDPIRRKLYSQEYRP-NWKNFTDLPANSDLIQV SmeWnt11a INYNSGIKWLGLAKLNRSHKQELDGFTRSECEYARKIQVLRK-RHFRFCLHHKHRFAMHA SmeWnt11b MDENYSIRWLGISRYTRPENQELERFSPLECRFNNLNHGLQK-RQTKFCLSLQHSYAMHG SmeWnt2b LVFIHESFPKHWIVKTLPITFTSPFQPNNIKQICSLISEESS-KEKNLCLTYPN--MMVS SmeWnt4 DIISIKVYVNSGRGMFFTLMKLQESTKFDLNNTNIFCNQLMK-LQRSICLRHVG--LIPS 'SmeWnt4.' SGRGLVYTMIQIHKIGTRHQGFQNTYANEYLSTSKICKRVLK-NQKPLCEEHFP--LMPS 'SmeWnt4..' SSNKYNHLSDSDPTSNPESSQNQQMTINNSPSKTVICQTFSL-HQRKLCHQHFR--LMES SmeWnt5 ----------MEVLPWKNQSPHSEKDSLEIKRICLRLSGYSK-DQALICTKYYD--HMPA SmeWntP-4 SPLFKISLGNSITNLHRIAILSQKNSSNSTPFICDRIRFENS-IYSRLCSEKPE--VINL CteWnt1 IAKAARMAVDECQRQFSTRRWNCPVYDASH----------------------GSSIFGKV CteWnt10 AVQGLKMAMEECQFQFREHRWNCTSMTKK---------------------H-NSPYGNRL CteWnt11 VAHATRQTTDVCQYLFAQYRWNCTSVR-------------------------MAPKYLPD CteWnt16 VSYGARVGIEECHHQFKKERWNCTTPEDEATG--------------------GINLFGQI CteWnt2 VVFGAKKGVKQCQRQFRHHRWNCSVS------------------------HTDSSVFGKL CteWnt4 VKKGAVSAIDECQYQFQNRRWNCSTV------------------------DHGSAVFGNV CteWnt5 VSAGAKIALGECQQQFHSRRWNCSLM------------------------EGNGAVFGPV CteWnt6 VANGAKMAISECQHQFRHRRWNCTT---------------------------ANRSIQRV CteWnt7 AGQGAKLAFEECSYQFRLHRWNCTIT------------------------DNTAGRTSPL CteWnt8 VSSGTQLGLRECQEQFKWERWNCPLK------------------------QSVLRPFNAR CteWnt9 LLDSVRLSVVECQANFKFDRWNCS----------------------------LGKPRINM CteWntA ------MGIDECQHQFRDRRWNCTTYN-------------------------DTDVFGKV EgrWnt1 ----------------VIDTWDIQDL------------------------E-VDPDFDIL EgrWnt11a VLRAARAVGFHCPDTFSNRRWNCSSV------------------------E-ALPRMSPE EgrWnt11b VLKSAQAVTYYCPHIFKDRRWNCSSVE-------------------------YLPKVTPD 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ------------------------------------------------------------ EgrWnt5 ------------------------------------------------------------ 'EmuWnt1.ORF' ----------------VIDTWATQDL------------------------E-VYPDFDIL 'EmuWnt11.1' VLRAARAVGFHCPDTFSDRRWNCSSVE-------------------------ALPRISPE 'EmuWnt11.2' VLKSAQAVTYYCPHIFKDRRWNCSSVE-------------------------YLPKVTPD 'EmuWnt2/5/8/10.ORF' ------------------------------------------------------------ EmuWnt4 ------------------------------------------------------------ EmuWnt5 ------------------------------------------------------------ HmiWnt1 ------------------------------------------------------------ HmiWnt11a VLRAARAVCYHCPDTFSDRRWNCSSV------------------------E-ALPHVSPE HmiWnt11b VLKSAQAVTYYCPEIFKDRRWNCSSV------------------------E-FLPKTSPD HmiWnt2 ----------------------------------------------------IGSLQKTL HmiWnt4 ------------------------------------------------------------ HmiWnt5 VSIGARIGILQCEDQFKFRHWNCTSGK-------------------------DAFSIGTH HroWnt1 ------------------------------------------------------------ HroWnt10 ------IALSECRYQFKNELWDC------------------------------------- HroWnt11a VVQAAKQTIDVCQEIFFEKRWNCSTIL-------------------------NAAKFLRD HroWnt11b LAETSKNVVELCERAFQFKRWNCSSVR-------------------------LAPRFKRD HroWnt11C -----------------------------------------------------------D HroWnt16a ------------------------------------------------------------ HroWnt16b --------------QFEEERWNCRLLDGATK---------------------DENILETI HroWnt2 VIHGLKMSIKECKRLFKYRRWNCTTF-----------------------AN-GPHVFGKM HroWnt4 ------ESIQACRAEFEGERWNC------------------------------------- HroWnt5a ---------DECFQQFGGMRWNCSLLSRAN--------------------KSSFMTLPDY HroWnt5b ------MGIGECQHQFKDRRWNC------------------------------------- HroWnt6 ------------------------------------------------------------ HroWnt7 VGEGAELGIEECRQQFSSRRWNCSSSE-------------------------NEPPLMFM LgiWnt1 IAKGAKMAIDECKYQFKNRRWNCPTYVDGH----------------------GGSIFGKI LgiWnt10 ------------------------------------------------------------ LgiWnt11 IVGASLLSVETCQNQFSDRRWNCSSIS-------------------------QVPSVPRD LgiWnt16 IGEGARRGILECQKQFKFERWNCTLI------------------------G-NNTVFGHV LgiWnt2 LREGARLGVEECQYQFQDHRWNCSTL------------------------HRDASVFGKS LgiWnt4 VKVGARVAIEECQSQFGNRRWNCSTAN-------------------------SKKLFGNV LgiWnt5 IGRGAQLGIHECQYQFRNRRWNCSTV------------------------D-DSSVFGPV LgiWnt6 VAKGAKVALMECQYQFRTRKWNCTTL---------------------------RRSLSKI LgiWnt7 IGEGAKLGLTECQYQFRFMRWNCSTLD-----------------------S-NDSMFGYE LgiWnt9 LLEATRLAVIECQYQFKHERWNCSLG----------------------------QYRQNI LgiWntA ------MGIDECQHQFRDRRWNCTTFN-------------------------TTNVFGQI PduWnt1 VAKGARVAIHECQSQFRNRRWNCPTTEDGR----------------------GGSIFGDI PduWnt10 ------------------------------------------------------------ PduWnt11 VAGATREAVLTCQSLFADRRWNCSSI------------------------T-YAPNFLAD PduWnt16 ------------------------------------------------------------ PduWnt2 ------------------------------------------------------------ PduWnt4 VRKEPSNPIHECQFQFRNRRWNCSTV------------------------D-ASTIFGNV PduWnt5 ---GAQMGIRECQWQFRHRRWNCSTV------------------------D-DSSVFGPV PduWnt6 AVNGVRMALDECQVQFRDRRWNCSLV---------------------------PKSFNRI 'PduWnt7 - wnt7 CDS' VGQGASLASSECLFQFRKHRWNCSFP------------------------PGTEPIFGPV PduWnt8 VAAGVERGITQCQQQFKWDRWNCPRE--------------------------GVNVFKPK 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA ------------EYQFSDRRWNCTTFN-------------------------NTSVFGKV PvuWnt1 ---VQWWSLANIGHRTNDLRTSANQLY-------------------------NNPSLLPL PvuWnt10 ------------------------------------------------------------ PvuWnt2 ------------------------------------------------------------ PvuWntA ------------------------------------------------------------ SmaWnt1 ------------------------------------------------------------ SmaWnt11 ------------------------------------------------------------ SmaWnt11b VLRAAHAVGYHCPKTFSDRRWNCTSIH-------------------------QLPHVSPE 'SmaWnt2(d)' MLEGTHLGMHECVHQFKHEQWNCSAVNLLYRTHIKSSSLS------------LTHGLEGI 'SmaWnt4(d)' VIRGYFMGLKECEYQFSAHRWNCQGH--------------------------NLTVQTPP SmaWnt5 ISIGAKLGIYECQRQFRFRHWNCSSDN-------------------------EASAFGPV SmeWnt1 AIEGIRKGIYTCQKLFANHRWNCPTPNLN---------------------NPSALLFGDI SmeWnt11a VLMASKATVYYCMKTFADRRWNCKSVE-------------------------KLPKLPPD SmeWnt11b VLRASKAAVFYCMKTFQDRRWNCSSA------------------------E-RLPYIGKD SmeWnt2b IVYGAKLGLVECAQQFKYERWNCTFN------------------------K-SFPKIMTN SmeWnt4 VIHGVDIGIQECQHQFFNSYWNCAGH--------------------------NLSIPDRF 'SmeWnt4.' VISGFMLGINECQFQFANHVWNCQGHNKTNNQQISLLQMSNTYIQKKPKRD-RKLRNTYM 'SmeWnt4..' VVNGFLLGLNECQFQFADQIWNCKGHNLTIGGHRTKSKPRK---------K-GKTYLDKL SmeWnt5 VSIGARIGIEECQRQLKYRQWNCSIPH-------------------------NSDVYGGF SmeWntP-4 IAMATSAALEECNKQLKYHRWDCGC---------------------------SNRLFQQI CteWnt1 VRKG--------------IR--ECAFIYAIMSAALAHSIARSCAEGS-IYTCTCGRHSR- CteWnt10 LHKG--------------YR--ETAFASAISAAGMSAQIALACAMGN-LPACGCNPRME- CteWnt11 LTGG--------------SR--EQAYVHALSAAALAQTISKACTQGA-TTKCSCGRIPN- CteWnt16 LKRG--------------TK--ETAFMYAVTSAGVVHAVTKACSSGN-LTDCTCDLSQQ- CteWnt2 MLKG--------------SK--EAAFVYAISSAGVVHAITRACSQGR-LTNCACDPTKT- CteWnt4 LNAG--------------TR--EAAFVHAISSAGVTYAVTKACSSGQ-VDKCGCDRSIR- CteWnt5 LDTG--------------SR--ESAFTYAIFAAGVVHAVSRSCRDGQ-LTNCGCSRRMR- CteWnt6 LKHD--------------TR--EAAFVHSLTSAGVLYAVTQACSLGL-LLQCMCDNSVM- CteWnt7 AAQHTIA-----------SK--EAAYTSAIRSAGVSYIITQACSQGS-IMSCGCDKTKG- CteWnt8 VQAD--------------TVTKEISFGQAITCAGVAHTITKNCSSGE-FENCRCDESKK- CteWnt9 LNKG--------------YK--ETAYLHALTSSSLVHTFSRACAQGR-LDRCTCDESFS- CteWntA LDLK--------------TR--EKAYIYAVSSAGVMFAVTTACAKGE-LHICDCDEKVR- EgrWnt1 YSFV--------------TGVPETAFVYALVSASVVRSVSEACLTN--LRNCPCNNRGR- EgrWnt11a LKR---------------TR--EQAIVHAYAAAALIFEIGRYCALNK-IRYCSCGMTGGT EgrWnt11b IARSKLSA----------TR--EKAAMHALASAALVFEIARRCAENK-IMDCECGRIDKW 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ------------------TR--ESAYVLAVTSAGISHAVTKACSSGM-HDSCGCDRTIY- EgrWnt5 ------------------TR--EASFAHAIASAGVVHALARSCKEAR-LSSCGCSKAER- 'EmuWnt1.ORF' YSFV--------------PGVPETAFVYALVSASVVRSVSEACLTN--LRNCPCNNRGR- 'EmuWnt11.1' LKR---------------TR--EQAIVHAYAAAALIFEIGRYCALNK-IRYCSCGMTGGT 'EmuWnt11.2' IARSKLSA----------TR--EKAAMHALASAALVFEIARRCAENK-IMDCECGRIDNW 'EmuWnt2/5/8/10.ORF' ------------------------------------------------------------ EmuWnt4 ------------------TR--ESAYVLAVTSAGISHAVTKACSSGM-HDSCGCDRTIY- EmuWnt5 ------------------TR--EASFAHAIASAGVVHALARSCKEAR-LLSCGCSKAER- HmiWnt1 -------------------GVPETAFVYALVSASVVRAISEACLTN--IRNCPCNNRGR- HmiWnt11a LKRGG-------------TR--EQAIVHAYAAAALVFEIGRYCALNK-IRYCSCGMT--- HmiWnt11b ISR---------------TR--EKAAMHALASAALMFEIGRRCAENK-IMDCECGRLDNW HmiWnt2 M-KS--------------TR--ETAFVTAAWAAGAVQAVTRACSRGR-ISTCDCDVTRR- HmiWnt4 ------------------TR--ESAYVLAVTSAGISHAVTKACSSGM-HDSCGCDRTIY- HmiWnt5 TRHGKFFNIYI-------TR--EASFVHAIASAGVVHAIARSCKEAR-LSSCGCSKAER- HroWnt1 ------------------------------------------------------------ HroWnt10 ------------------FK--ESSVIFALLGASVSTQISRACSAAD-LQYCGCTSAQL- HroWnt11a LTGG--------------SR--EQAFVYSLAAGSLAQTIAKACSSGL-TSKCGCAQIPT- HroWnt11b LTKAG-------------TR--EQSFVYSLSSSVFLLNLERYCHLGRIIERCRCAKRWH- HroWnt11C LTGG--------------SR--EQAVVYALASASLVQSIAKTCSSGY-STKCSCGRHPF- HroWnt16a ------------------------------------------------------------ HroWnt16b LQQG--------------TK--EIAFIHAITSASLAHSITSSCSAGL-LLECSCDRSVQ- HroWnt2 ELSG--------------HR--ESAFLQALTTASVVHTVHKRCYSGK-IKNCNCGSGGN- HroWnt4 -------------------R--ETAFLYAILSAGVTHKVTKACSSGR-LKNCGCDRTLE- HroWnt5a LPDG--------------CK--EASILKAFFSASMTFNVARACKDGQ-LHQCGCSRREK- HroWnt5b -------------------R--ESALLHAMMSAGVVHSISRMCRDGE-LTGCGCSKK--- HroWnt6 ------------------TDSREAALIRALTSAGILLKIFEACSRGQ-LSQCGCEKTIS- HroWnt7 TNIA--------------SK--ESAFVSAPRSAGIAYAITRACSRSD-LAGCACDKSVS- LgiWnt1 LNTG--------------CR--ETAFIYAATSAAVSHSIARACSEGS-IHTCSCDFEHN- LgiWnt10 ------------------------SFAYAISSAGVTHQVSKACSMGK-LKSCGCDMSVY- LgiWnt11 LSRG--------------TR--EQAYVYGIASAALTHSVARACSIGV-TRKCSCGALPN- LgiWnt16 LSKG--------------TR--EAAFIYAILSAGVVHSVTQSCSAGN-LTDCSCDMSKY- LgiWnt2 MLKG--------------TR--EAAFVYSISSAGVVYSITSACSKGE-LLHCACDPTKR- LgiWnt4 ILKQG-------------TR--EAAFVHAISSAGVAHSVTRACSSGT-LQKCGCDRTVR- LgiWnt5 LNIG--------------NR--EAGFTHSISAAGVVYAISRACREGE-LSKCGCSRARR- LgiWnt6 LRRD--------------TR--EAAFVYAITAAGVVYAVTEACSMGR-LLQCTCDNNLR- LgiWnt7 SLGG--------------TK--EAAFIYAMTSAGVSYAITQSCGLGS-LPNCGCDKDKG- LgiWnt9 LRRG--------------FS--ETSFLYAISSAGLVHAFARACSKGV-LDRCTCDESKH- LgiWntA LKIK--------------SR--ETGYIYAILSAGIMYSVTRACAKGD-LDHCGCDTKVR- PduWnt1 FKAAG-------------TR--ETAFIYAITAAGVTHSVARACSEGS-IFTCSCGRRRRI PduWnt10 ------------------------------------------------------------ PduWnt11 LTGG--------------SR--EQAFVYAISSAAITHAVSRACSIGA-TTKCGCGRLPS- PduWnt16 ------------------------------------------------------------ PduWnt2 ------------------------------------------------------------ PduWnt4 LHQG--------------SR--EASFVHAISSAGVAHPVTRACSSGT-MSECGCDRTVR- PduWnt5 LEIP--------------SR--EAAFINAISAAGVVHTVARSCRDGE-LSTCGCSRRPR- PduWnt6 LRKD--------------TR--ETAFVYALTAAGVLYSITHACSTGQ-SMQCSCDASVR- 'PduWnt7 - wnt7 CDS' QLAG--------------TK--EAAFMYAIRAAGVAFAITQSCSSGN-LTSCGCDKLRH- PduWnt8 NYVSV-------------TR--EVAFVHAITAAGVTYTLTRNCSAGH-IEKCSCDDSKK- 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA LSKK--------------TR--ERAYIYAVSSAGVMYSITKACAKGD-LHMCSCDTSIR- PvuWnt1 TKDN--------------GVSDTQSWTLAVTSAAVSSVHVRSEA----VFTCSCDYEHN- PvuWnt10 ------------------FG--TRSFAYAISAAGVTHQVSKACSMGK-LKSCGCDMSVY- PvuWnt2 ------------------AR-GEAAFVYSISSAGVVHAITRACSKGD-LLHCACDPTKR- PvuWntA -------------------R--TSG----------------------------------- SmaWnt1 -------------------K---------------------------------------- SmaWnt11 ------------------------------------------------------------ SmaWnt11b LRRG--------------TR--EQAIVHAFASSVLLFEIGRYCALNK-IRYCSCGDEDGS 'SmaWnt2(d)' LQRG--------------SR--ETAFLSSSWSAGVVQAITRACSRGQ-LGTCDCDPHRR- 'SmaWnt4(d)' NS----------------TR--ESAYVLAVTSAGVSHAVTKACSSGL-HDNCGCDRTIY- SmaWnt5 TLTG--------------SR--EAGFAHAISAAGVVHALARSCKEAR-LYSCGCSKADR- SmeWnt1 MLKG--------------FP--ETAFIYAMLSASVAQTVAEACSFK--LSHCPCNNKGR- SmeWnt11a LKLG--------------TQ--EQAVVHAFSSAALVFEISRRCSQNK-LRHCSCGKDES- SmeWnt11b LESGKKLIWFHGYIFQSGTQ--EQAVVHAFSSASLLFEIARRCAQNK-MAHCSCGTSNP- SmeWnt2b HLHEMTTRS---------VK--ETAFLFSIWSSGVVYSITNSCSKGD-LKECYCDPQRH- SmeWnt4 VSQSKKKHRKTYLDNLINKGLPESAFLLSMTSAAVAHQVSKACSSGQ-NKYCGCDRTIY- 'SmeWnt4.' DQLIAKS-----------TP--ESAFILSIISAGVSYQVTKACSQGV-HSNCGCDRTVY- 'SmeWnt4..' VSKG--------------TP--EAAYVSSVISAGVAHQVTKACSKGV-HDSCGCDRTIY- SmeWnt5 TYYS--------------TK--EAAFAHAISNAGVVHAIARSCKEGK-LSTCGCSDENR- SmeWntP-4 VEKY--------------SK--EAAYLNAITTAGITYYVTKACSRGD-LKFCQCSADQQ- CteWnt1 --------RLANSVQPRD------------------------------------------ CteWnt10 -------------TSTQQ------------------------------------------ CteWnt11 ------------EAPPSE------------------------------------------ CteWnt16 -----------GQTSGEG------------------------------------------ CteWnt2 ---------GSSSDRNGK------------------------------------------ CteWnt4 -----------GKSPQG------------------------------------------- CteWnt5 -----------PKTLHRD------------------------------------------ CteWnt6 -----------DRSTDGK------------------------------------------ CteWnt7 ---------DTSNAFSSE------------------------------------------ CteWnt8 -----------GKKGGRT------------------------------------------ CteWnt9 -----------ASKNKEA------------------------------------------ CteWntA -----------SQDTKGG------------------------------------------ EgrWnt1 -------ESFEGGYDMVN------------------------------------------ EgrWnt11a EMIISPEGGQMSRFPQGYVPSPRVRRQLDMANFRKFSDAISFQPEVSHSQHQKQFQQMQT EgrWnt11b NVPPQPQEIDDPGPSDANQPQDVPVQ---------------------------------- 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 -----------DHERQPN------------------------------------------ EgrWnt5 -----------PQQLHRD------------------------------------------ 'EmuWnt1.ORF' -------ESFEGGYDMVN------------------------------------------ 'EmuWnt11.1' EMIISPEGGQMSRFPQGYVPSPRVRRQLDMANFRKFSDAISFQPEVSHPQHQKQFQQMQT 'EmuWnt11.2' NVPPQPQEIDDPGPSDANQPQDVPVQ---------------------------------- 'EmuWnt2/5/8/10.ORF' ------------------------------------------------------------ EmuWnt4 -----------DHERQPN------------------------------------------ EmuWnt5 -----------PQQLHRD------------------------------------------ HmiWnt1 -------ESFEKVGDVMN------------------------------------------ HmiWnt11a ------------------------------------------------------------ HmiWnt11b DIPPQPADIDDPGPVDLKQPQNVPLQ---------------------------------- HmiWnt2 -------GGLKAADTEGP------------------------------------------ HmiWnt4 -----------DHERQPN------------------------------------------ HmiWnt5 -----------PQQLHRD------------------------------------------ HroWnt1 ------------------------------------------------------------ HroWnt10 ----------------RR------------------------------------------ HroWnt11a ------------EPAPGN------------------------------------------ HroWnt11b -----------ESDDTRL------------------------------------------ HroWnt11C -----------DEPPAAD------------------------------------------ HroWnt16a ------------------------------------------------------------ HroWnt16b ----------SIVSTDSS------------------------------------------ HroWnt2 ------SDAIRKRFVTSS------------------------------------------ HroWnt4 ------------------------------------------------------------ HroWnt5a -----------PRHLPAE------------------------------------------ HroWnt5b ----------------KE------------------------------------------ HroWnt6 ----------------RP------------------------------------------ HroWnt7 ---------------KSD------------------------------------------ LgiWnt1 -----------KVPVGKD------------------------------------------ LgiWnt10 -------------GNQQN------------------------------------------ LgiWnt11 ------------TAPTGA------------------------------------------ LgiWnt16 -----------GRENKGEG----------------------------------------- LgiWnt2 ---------GTSKDSKGE------------------------------------------ LgiWnt4 -----------GRSPEG------------------------------------------- LgiWnt5 -----------PKDLHRD------------------------------------------ LgiWnt6 -----------DIATDGE------------------------------------------ LgiWnt7 ----------DGKLAPQG------------------------------------------ LgiWnt9 ------------LENHKT------------------------------------------ LgiWntA -----------RISTEGE------------------------------------------ PduWnt1 DVTSSLPTSAASIPPAAT------------------------------------------ PduWnt10 ------------------------------------------------------------ PduWnt11 ------------EPPPGD------------------------------------------ PduWnt16 ------------------------------------------------------------ PduWnt2 ------------------------------------------------------------ PduWnt4 -----------GRSPAG------------------------------------------- PduWnt5 -----------PKGLHRD------------------------------------------ PduWnt6 -----------DRRNDGS------------------------------------------ 'PduWnt7 - wnt7 CDS' ------QAGGGRRPSQQD------------------------------------------ PduWnt8 -----------GTRGGAN------------------------------------------ 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA -----------NKETKGE------------------------------------------ PvuWnt1 -----------KVPVGKD------------------------------------------ PvuWnt10 -------------GNDKN------------------------------------------ PvuWnt2 ---------GSSKDSRGE------------------------------------------ PvuWntA ------------------------------------------------------------ SmaWnt1 ------------------------------------------------------------ SmaWnt11 ------------------------------------------------------------ SmaWnt11b YATPNYPSSHLYKNNNNNLLRQQTLYNDNNNALVYNSDGHSMNSIDTSKSNNIPMTDGQP 'SmaWnt2(d)' --------EGQGRDAEGI------------------------------------------ 'SmaWnt4(d)' -----------DHPREPN------------------------------------------ SmaWnt5 -----------PDQLHRD------------------------------------------ SmeWnt1 -------------ISQTN------------------------------------------ SmeWnt11a -----------DANVGSNNQNYT------------------------------------- SmeWnt11b --------TANQEITQEK------------------------------------------ SmeWnt2b ---------GQDKDNVGD------------------------------------------ SmeWnt4 ------------ETPEDN------------------------------------------ 'SmeWnt4.' -----------DAPKDSK------------------------------------------ 'SmeWnt4..' -----------DTPESER------------------------------------------ SmeWnt5 -----------PEDLHRD------------------------------------------ SmeWntP-4 -----------DLSGMNK------------------------------------------ CteWnt1 -----WEWGGCS----DNAEFGRKFSHDFI------------------------------ CteWnt10 -----WVWKGCQ----HNVRFGDYFTRKFW------------------------------ CteWnt11 -----FKWGGCG----DDLRFGMIFSASFA------------------------------ CteWnt16 -----WKWGGCS----DNVDYGMWFAETFV------------------------------ CteWnt2 -----FDWGGCS----DNVRYGSHFARMFV------------------------------ CteWnt4 -----FEWAGCS----DNVAYGSAFCGMFV------------------------------ CteWnt5 -----WLWGGCG----DNTDYGYRFAQGFV------------------------------ CteWnt6 -----WEWAGCN----EDVRFGSRKAAEFL------------------------------ CteWnt7 -----WKWGGCS----ADIKYGLTFSRLFL------------------------------ CteWnt8 -----WKWGGCS----DNLRFGERVSKLFF------------------------------ CteWnt9 -----WLWGGCG----DNIQYGMKFARRFL------------------------------ CteWntA -----FIWGGCS----HNVAFGDRFTREFV------------------------------ EgrWnt1 -----WQWQGCD----HNIHFGRRFGRYLL------------------------------ EgrWnt11a QVQNTHYWSGCP----DNVDTARSYVAQFL------------------------------ EgrWnt11b -----YHWGGCS----DNVETAKTYTQAFL------------------------------ 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 -----FEWSGCS----DNIHFGAAFSRKFL------------------------------ EgrWnt5 -----WIWGGCG----DNIDYAYRFSKAFV------------------------------ 'EmuWnt1.ORF' -----WQWQGCD----HNIHFGRRFGRYLL------------------------------ 'EmuWnt11.1' QVQNTHYWSGCP----DNVDTARSYVAQFL------------------------------ 'EmuWnt11.2' -----YNWGGCS----DNVETAKTYTQAFL------------------------------ 'EmuWnt2/5/8/10.ORF' -------FGNIG---------GISLSTLIR------------------------------ EmuWnt4 -----FEWSGCS----DNIHFGAAFSRKFL------------------------------ EmuWnt5 -----WIWGGCG----DNIDYAYRFSKAFV------------------------------ HmiWnt1 -----WQWQGCD----HNIHYGRRFGRRLL------------------------------ HmiWnt11a --------GGTEMIISPEGGQMSRFPQGYT------------------------------ HmiWnt11b -----YHWGGCS----DNVEAAKTYTQAFL------------------------------ HmiWnt2 -----FTWGGCS----DPIRFGMRLVRLFQ------------------------------ HmiWnt4 -----FEWSGCS----DNIHFGAAFSRKFL------------------------------ HmiWnt5 -----WIWGGCG----DNIDYAYRFSKAFV------------------------------ HroWnt1 -------WDGCN----DNDIFGSEFTREFI------------------------------ HroWnt10 -----YS-QACQ----SSLTYGDVMRKKFM------------------------------ HroWnt11a -----FRWGGCR----DDVKFGVAFSRQFT------------------------------ HroWnt11b -----FNAKSNGVEKCNRIRYVGKISRSFT------------------------------ HroWnt11C -----FKWGGCG----DDVRFSVDFSHKFT------------------------------ HroWnt16a -----WKWGGCS----DDIDYGLSYAKLFT------------------------------ HroWnt16b -----WRWGGCS----DNVQYAIKYSKIIT------------------------------ HroWnt2 -----FKWSGCR----DELAFGEKFARDFI------------------------------ HroWnt4 -------WSGCS----DNVAYGKAFARSLI------------------------------ HroWnt5a -----WVWGGCG----DNTEYGFKFGVGFV------------------------------ HroWnt5b -----WIWGGCG----DNTDYGYKFSGGFV------------------------------ HroWnt6 -----QIWRSCA----GVVSFAATIAQTFT------------------------------ HroWnt7 -----WEWNGCS----ANVNYGIKFCENFL------------------------------ LgiWnt1 -----WEWSGCS----DNARYGHKFSRRFV------------------------------ LgiWnt10 -----FEWGGCS----HNINFGAKYASKFL------------------------------ LgiWnt11 -----FKWGGCG----DDLHFGMALGRAFT------------------------------ LgiWnt16 -----FQWGGCS----DNVDYGLKFSRGFV------------------------------ LgiWnt2 -----FDWGGCS----DSVRFGSRFSRMFV------------------------------ LgiWnt4 -----FEWSGCS----DNIDYGMAFSKAFV------------------------------ LgiWnt5 -----WIWGGCG----DNIEYGYKFAKAFV------------------------------ LgiWnt6 -----WEWGGCG----DNVDFGYQKSREFM------------------------------ LgiWnt7 -----WKWGGCS----ADIKHGLRLARKFM------------------------------ LgiWnt9 -----WLWGGCG----DNLRYGLKFTRKFL------------------------------ LgiWntA -----FEWGGCS----DNIRYGSKFSKDFV------------------------------ PduWnt1 -----WEWGGCS----DNIEFGQRFSREFV------------------------------ PduWnt10 ------------------------------------------------------------ PduWnt11 -----FKWGGCG----DDLRFGLAYADLFA------------------------------ PduWnt16 ------------------VDYGVWFAKTFV------------------------------ PduWnt2 -------------------RYGAKFSRLFI------------------------------ PduWnt4 -----FEWAGCS----DNIAFGTAFSRTFV------------------------------ PduWnt5 -----WIWGGCG----DNSEYGYRFAEGFI------------------------------ PduWnt6 -----FEWGGCS----DNVRFGYQKTRDLL------------------------------ 'PduWnt7 - wnt7 CDS' -----FNWGGCS----VDVRYGLKFSRVFI------------------------------ PduWnt8 -----WLWGGCS----DNVHFGERISRLFL------------------------------ 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA -----FLWGGCS----HNVKFGERFTREFV------------------------------ PvuWnt1 -----WEWSGCS----DNARYGHRFSRRFV------------------------------ PvuWnt10 -----FEWGGCS----HNIEFGSRYARRFM------------------------------ PvuWnt2 -----FDWGGCS----DNVRFGSHFVRMFV------------------------------ PvuWntA -------------------------SPGLQ------------------------------ SmaWnt1 ------------------------------------------------------------ SmaWnt11 -----------------------NFIISFL------------------------------ SmaWnt11b TVSK-FYWAGCS----DNLRTAKEYTSLFLGFPNVHVMLPPPMETDNPNLDSIQDMNNQN 'SmaWnt2(d)' -----FTWGGCS----DPIRFGMRLARLFL------------------------------ 'SmaWnt4(d)' -----FEWSGCS----DNIYFGAEFSRQFL------------------------------ SmaWnt5 -----WIWGGCG----DNIAYAYRFAKAFI------------------------------ SmeWnt1 -----WIWQGCD----DNVQFGRRFARKMF------------------------------ SmeWnt11a -----YYYSNCL----DNIDIGIESTRNFL------------------------------ SmeWnt11b -----LLFAGCP----DNVEIGLEYVRKFT------------------------------ SmeWnt2b -----FTWGGCS----DHIKFGMKVSTIFL------------------------------ SmeWnt4 -----FQWAGCS----DNVHFGAAFSKRFL------------------------------ 'SmeWnt4.' -----FTWSGCS----HNIHFGAAFSRRFL------------------------------ 'SmeWnt4..' -----FKWSGCS----HNIHFGAAFTRQFL------------------------------ SmeWnt5 -----WLWGGCG----DNLKYAYWFAKNFI------------------------------ SmeWntP-4 -----DQLTNCN----ENVDYGKSFTEIFL------------------------------ CteWnt1 ------------------------------------------------------------ CteWnt10 ------------------------------------------------------------ CteWnt11 ------------------------------------------------------------ CteWnt16 ------------------------------------------------------------ CteWnt2 ------------------------------------------------------------ CteWnt4 ------------------------------------------------------------ CteWnt5 ------------------------------------------------------------ CteWnt6 ------------------------------------------------------------ CteWnt7 ------------------------------------------------------------ CteWnt8 ------------------------------------------------------------ CteWnt9 ------------------------------------------------------------ CteWntA ------------------------------------------------------------ EgrWnt1 ------------------------------------------------------------ EgrWnt11a ------------------------------------------------------------ EgrWnt11b ------------------------------------------------------------ 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ------------------------------------------------------------ EgrWnt5 ------------------------------------------------------------ 'EmuWnt1.ORF' ------------------------------------------------------------ 'EmuWnt11.1' ------------------------------------------------------------ 'EmuWnt11.2' ------------------------------------------------------------ 'EmuWnt2/5/8/10.ORF' ------------------------------------------------------------ EmuWnt4 ------------------------------------------------------------ EmuWnt5 ------------------------------------------------------------ HmiWnt1 ------------------------------------------------------------ HmiWnt11a ------------------------------------------------------------ HmiWnt11b ------------------------------------------------------------ HmiWnt2 ------------------------------------------------------------ HmiWnt4 ------------------------------------------------------------ HmiWnt5 ------------------------------------------------------------ HroWnt1 ------------------------------------------------------------ HroWnt10 ------------------------------------------------------------ HroWnt11a ------------------------------------------------------------ HroWnt11b ------------------------------------------------------------ HroWnt11C ------------------------------------------------------------ HroWnt16a ------------------------------------------------------------ HroWnt16b ------------------------------------------------------------ HroWnt2 ------------------------------------------------------------ HroWnt4 ------------------------------------------------------------ HroWnt5a ------------------------------------------------------------ HroWnt5b ------------------------------------------------------------ HroWnt6 ------------------------------------------------------------ HroWnt7 ------------------------------------------------------------ LgiWnt1 ------------------------------------------------------------ LgiWnt10 ------------------------------------------------------------ LgiWnt11 ------------------------------------------------------------ LgiWnt16 ------------------------------------------------------------ LgiWnt2 ------------------------------------------------------------ LgiWnt4 ------------------------------------------------------------ LgiWnt5 ------------------------------------------------------------ LgiWnt6 ------------------------------------------------------------ LgiWnt7 ------------------------------------------------------------ LgiWnt9 ------------------------------------------------------------ LgiWntA ------------------------------------------------------------ PduWnt1 ------------------------------------------------------------ PduWnt10 ------------------------------------------------------------ PduWnt11 ------------------------------------------------------------ PduWnt16 ------------------------------------------------------------ PduWnt2 ------------------------------------------------------------ PduWnt4 ------------------------------------------------------------ PduWnt5 ------------------------------------------------------------ PduWnt6 ------------------------------------------------------------ 'PduWnt7 - wnt7 CDS' ------------------------------------------------------------ PduWnt8 ------------------------------------------------------------ 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA ------------------------------------------------------------ PvuWnt1 ------------------------------------------------------------ PvuWnt10 ------------------------------------------------------------ PvuWnt2 ------------------------------------------------------------ PvuWntA ------------------------------------------------------------ SmaWnt1 ------------------------------------------------------------ SmaWnt11 ------------------------------------------------------------ SmaWnt11b RYKRSTYSSHVTESSYDTTEISDMFSPFQNQINVNENVDDRVREEDPDEEIEENEGEDDS 'SmaWnt2(d)' ------------------------------------------------------------ 'SmaWnt4(d)' ------------------------------------------------------------ SmaWnt5 ------------------------------------------------------------ SmeWnt1 ------------------------------------------------------------ SmeWnt11a ------------------------------------------------------------ SmeWnt11b ------------------------------------------------------------ SmeWnt2b ------------------------------------------------------------ SmeWnt4 ------------------------------------------------------------ 'SmeWnt4.' ------------------------------------------------------------ 'SmeWnt4..' ------------------------------------------------------------ SmeWnt5 ------------------------------------------------------------ SmeWntP-4 ------------------------------------------------------------ CteWnt1 ---------------D-------VAEK--------------------------------G CteWnt10 ---------------G-------SKKE--------------------------------A CteWnt11 ---------------D------------------------------------SPFLKRKK CteWnt16 ---------------D-------APEK---------------------------LRHTAS CteWnt2 ---------------D-------AREK-------------------------------RV CteWnt4 ---------------D-------ARER-----------------------------AKGR CteWnt5 ---------------D-------IRER------------------------EKNHPRHSP CteWnt6 ---------------D-------IPPT-------------------------------QR CteWnt7 ---------------D-------SKEV--------------------------------K CteWnt8 ---------------D-------DRVA--------------------------------A CteWnt9 ---------------R-------WMRK--------------------------------S CteWntA ---------------D-------SNEN--------------------------------R EgrWnt1 ---------------D-------PLEA-------------------------------GG EgrWnt11a ---------------G-------------------------------------------- EgrWnt11b ---------------GLPSENRPQRRR-----SRYVMDVYGRYGRVPRQTIKAPQKQNSR 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ---------------D-------SRER--------------------------------G EgrWnt5 ---------------D-------IREK------------------------EKSFPRNSL 'EmuWnt1.ORF' ---------------D-------PLEA-------------------------------GG 'EmuWnt11.1' ---------------G-------------------------------------------- 'EmuWnt11.2' ---------------GLPLENRPQKRR-----SRYVMDVYARYGRVPRQTMKALRKQNSR 'EmuWnt2/5/8/10.ORF' ---------------P-------------------------------------------- EmuWnt4 ---------------D-------SREK--------------------------------G EmuWnt5 ---------------D-------IREK------------------------EKSFPRNSL HmiWnt1 ---------------D-------PLET-------------------------------GG HmiWnt11a ---------------P-------SKRV--------------------------------- HmiWnt11b ---------------GFPAETRPQRRQ----MRYVLHPYGRYSRVPRQTVRQMNKKRNSK HmiWnt2 ---------------E-------PR----------------------------------- HmiWnt4 ---------------D-------SREK--------------------------------G HmiWnt5 ---------------D-------LREK------------------------EKSFPRNSL HroWnt1 ---------------D-------RGEK--------------------------------Y HroWnt10 ---------------E-------RRS---------------------------------- HroWnt11a ---------------D-------QTES-----------------------------RRKK HroWnt11b ---------------D-------GSLKAIQHRIISSINSSNDSSNFASKIKLESNSRKTL HroWnt11C ---------------D-------KFWQ--------------------------KKLKEKK HroWnt16a ---------------D-------------------------------------------- HroWnt16b ---------------D-------GGNK-----------------------QKDGKKAALM HroWnt2 ---------------D-------DENE------------------------------VGP HroWnt4 ---------------D-------VREE--------------------------------- HroWnt5a ---------------D-------SRER------------------------EMNYPRYSH HroWnt5b ---------------D-------VMEK--------------------------------- HroWnt6 ---------------E-------SSDF------------------------------GSR HroWnt7 ---------------D-------AREK-------------------------------YS LgiWnt1 ---------------D-------VLEK--------------------------------G LgiWnt10 ---------------D-------SKER-------------------------------TS LgiWnt11 ---------------D-------ASLK--------------------------SKKGKSK LgiWnt16 ---------------D-------APEI---------------------------VRHEDS LgiWnt2 ---------------D-------AKEK-------------------------------RV LgiWnt4 ---------------D-------AREK----------------------------GKKRK LgiWnt5 ---------------D-------MREK------------------------EKNHPRHSR LgiWnt6 ---------------D-------ARRR-----------------------------KRRR LgiWnt7 ---------------D-------AREI--------------------------------A LgiWnt9 ---------------K-------RARK-------------------------------SG LgiWntA ---------------D-------SKEM--------------------------------R PduWnt1 ---------------D-------LVEK--------------------------------G PduWnt10 ------------------------------------------------------------ PduWnt11 ---------------A-------PGGK------------------------------GKR PduWnt16 ---------------D-------AVEK--------------------------------E PduWnt2 ---------------D-------AREK-------------------------------RV PduWnt4 ---------------D-------ARER--------------------------VRKDREG PduWnt5 ---------------D-------ARER------------------------EKNHPRHSN PduWnt6 ---------------D------VVRKR-----------------------RKNKKGRRKR 'PduWnt7 - wnt7 CDS' ---------------D-------AREV--------------------------------D PduWnt8 ---------------D-------SRVT--------------------------------G 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA ---------------D-------TKEN--------------------------------G PvuWnt1 ---------------D-------VIEK--------------------------------G PvuWnt10 ---------------D-------SKEV--------------------------------A PvuWnt2 ---------------D-------AKER-------------------------------KV PvuWntA ---------------D-------SARV--------------------------------R SmaWnt1 ------------------------------------------------------------ SmaWnt11 ------------------------------------------------------------ SmaWnt11b EIDDSKLFHLQHEYTDRRRRNLHKTWSYQSTAQTNKYPSYSSAQQMYDSIDD????SKQG 'SmaWnt2(d)' ---------------D-------ANDE--------------------------------- 'SmaWnt4(d)' ---------------D-------VRER----------------------------NRLKR SmaWnt5 ---------------D-------VREK------------------------EKSYPRHSN SmeWnt1 ---------------D---------------------------------------PDIPD SmeWnt11a ---------------GFHQMGMKSKDS---------------------DSKSENKKPNKQ SmeWnt11b ---------------G---YHKLGRKK-----------SKEKPRKEKFSFYVAEKRAKMQ SmeWnt2b ---------------D-------NYDR-------------------------------KD SmeWnt4 ---------------D-------SPHK----------------------------RKIKR 'SmeWnt4.' ---------------D-------AREK----------------------------IRLKK 'SmeWnt4..' ---------------D-------VPDK----------------------------IRVSK SmeWnt5 ---------------D-------IREK------------------------ESSFPRGSN SmeWntP-4 ---------------D-------GPVK-----------LSIKSLIRMNIKTKMEKRKKSR CteWnt1 RDLKCL--MNLHNSEAGRT---------QVSSEMSKECKCHGM-SGSCTVKTCWMKLPMF CteWnt10 TNVYSE--MDVHNSRAGRM---------IWRENVRLHCKCHGM-SGSCEVRTCWKAASSF CteWnt11 RSKQAM--MNLHNNNAGRK---------IISDSLVTDCKCHGV-SGSCNIKTCWKALPDM CteWnt16 KDIRSL--MNLQNNAVGRQ---------VINDQMNLKCRCHGV-SGSCAVKTCWRTLTSF CteWnt2 KDARAL--MNLQNNRAGRR---------AVRRHMTLECKCHGV-SGACTIRTCWLALQEF CteWnt4 QSSRAL--MNLHNNEAGRL---------AVEENMKVQCKCHGV-SGSCEMKTCWRGLPSF CteWnt5 ELARTL--MNLHNNEAGRR---------AVYSHTVVACKCHGV-SGSCSLKTCWNQLAPF CteWnt6 NDVQGR--ILLHNNKAGRA---------SVAKYQQKICKCHGL-SGSCELKTCVLKMPSF CteWnt7 EDERAL--MNLHNNRAGRK---------AVKSQMDTQCKCLGV-SGACTIKTCWTTLPGF CteWnt8 TDAMAT--VNLHNNEVGRT---------ALKKTMELICKCHGV-SGSCTTKTCWQHLSDF CteWnt9 LDLQAT--ADSHNSDVGIR---------VVRNGINKTCKCHGV-SGSCTVQTCWRQLANF CteWntA FNDEGL--MNLWNNNAGRK---------AIRTSMKLLCKCHGV-SGSCSAKICWKTMTGF EgrWnt1 FHIRFL--MNLHNYRVGRR---------VVAENMQRYCRCHGT-SGSCTLKTCYRRTPSM EgrWnt11a --------FAFQ----------------MMIALQKQSCKCHGV-SGSCTQKVCFRQLQRI EgrWnt11b KRKRKI--VNLHNYMAGIKVSHESIQ--IIEGSQKIRCKCQGV-SGSCAHKICFRQLLRV 'EgrWnt2/10' -----L--MNLHNYRVGRR---------VVAENMQRYCRCHGT-SGSCTLKTCYRRTPSM EgrWnt4 RVQRVQ----------------------AVVKKMDIKCKCHGV-SGSCEMRTCWRALPDF EgrWnt5 GLARKL--MNLHNNRVGRLV--------SRSAHEIVACKCHGM-SGSCSLRTCWTQLSPF 'EmuWnt1.ORF' FHIRFL--MNLHNYRVGRR---------VVAENMQRYCRCHGT-SGSCTLKTCYRRTPSM 'EmuWnt11.1' --------------------------------FQKQSCKCHGV-SGSCTQKVCFRQLQRI 'EmuWnt11.2' KRTRKI--VNLHNYMAGIKVSYESIQ--IIEGSQKIRCKCQGV-SGSCAQKICFRQLLRV 'EmuWnt2/5/8/10.ORF' --FKTL--LTLLYSPPLQF----------IWQSREKKCKCHGI-SGACTLRTCWQRVGTF EmuWnt4 RVQRVQ----------------------AVVKKMDIKCKCHGV-SGSCEMRTCWRALPDF EmuWnt5 GLARKL--MNLHNNRVGRLV--------SPSAHQIVACKCHGM-SGSCSLRTCWTQLSPF HmiWnt1 FHIRFL--MNLHNYRAGRR---------VVSENMQRYCRCHGT-SGSCTLKTCYRRTPSM HmiWnt11a ----------------------------MMISLQKQSCKCHGV-SGSCTQKVCFRQLQRI HmiWnt11b KKTKRL--VNLHNYRAGMK---------IIEDSQKIRCKCQGV-SGSCAHKICFRQLLRI HmiWnt2 --------------------------------------------------------LPSS HmiWnt4 RVQRLK----------------------AVVNKMDIKCKCHGV-SGSCEMRTCWRALPDF HmiWnt5 NLARKL--MNLHNNRVGRLVSSYKYCLCAVYKLATVACKCHGM-SGSCSLRTCWTQLSPF HroWnt1 RDLKSG--VLKHNSRAGRQ---------HVLQNMQKECKCHGM-SGTCSLKTCWMKMPSI HroWnt10 --------LRQHNENLGRK---------LVKKMAIVRCKCHGV-SGSCQLKTCWKVAPDF HroWnt11a RSKDVL--MNVDNAHVGRK---------MLADSIAAICKCHGV-SGSSSLKTCFKSLPAL HroWnt11b SAVGVL--TRLHNTAVGRK---------IITKSLAKYCRCHGT-SGSCNVKVCWMAFNMT HroWnt11C LKKLAM--INLHNNRVGRQ---------VMSTSLGTSCKCHGV-SGSCSVKTCWKSLPDL HroWnt16a ---KPI--KDLHNNEVGRQ---------ILSSLMKIKCPCHGV-SGLCGVRTCWKSLRTF HroWnt16b ERVRSV--VHLHNNDVGRK---------TFHSLMTHKCRCHGV-SGSCAVRSCWRSLPRF HroWnt2 KSGLDL--MRMRNNAAGRR---------AVRKSLRLNCTCYGA-SGSCTVRTCWNSTAEF HroWnt4 ---------NLHNNNAGRK---------TVELSMRTHCRCHGV-SGSCEMKTCWKTLPPF HroWnt5a ELKIML--SNLHNNMVGRR---------TVVGLSKASCRCHGA-SGSCSMKTCWHQMADF HroWnt5b ---------NLHNNEVGRS---------EVYRHVKIGCKCHGT-SGSCSVRTCWNQLPSF HroWnt6 RDFKSI--LHRHNHRVGRL---------LSTSPTRQHCKCHGL-SASCTIFTCWQKLPTF HroWnt7 DNSQSL--MNLHNNRPGRK---------VLRSSMKRNCKCSGV-SGSSSVKTCWTSLHLM LgiWnt1 RDFRYM--MNLHNNEAGRV---------HVSSGMKQECKCHGM-SGSCTIKTCWMRLPPF LgiWnt10 RDIHAQ--INLHNNRAGRL---------AIIRHVRKQCKCHGM-SGSCELKTCWKAAPDF LgiWnt11 SSKKAM--MNRHNFAAGRK---------IVESSLTTACKCHGV-SGSCSIKTCWKSLPDF LgiWnt16 RDIRNL--MNLHNNEVGRQ---------IVEKNMQLRCRCHGV-SGSCAVRTCFRSLPNF LgiWnt2 SDARAL--MNLHNNRAGRR---------AVRRFRKLMCKCHGI-SGSCTLRTCWLAMEDF LgiWnt4 NTGRAL--MNLHNNEAGRK---------AVDANMKVECKCHGV-SGSCEMRTCWKAMPSF LgiWnt5 DLSRML--MNVHNNEAGRR---------AVYNFAKVACKCHGV-SGSCSLKTCWQHLPNF LgiWnt6 GDVTTL--VQLHNNEAGRQ---------AVRKYMRKECKCHGL-SGSCTLKTCWRKMPLF LgiWnt7 QNARSL--MNLHNNRAGRK---------AVKDNMGTDCKCHGV-SGSCTMKTCWTTLPPF LgiWnt9 KDVRAK--VNQHNSRVGIK---------VVKENVNTTCKCHGV-SGSCTVKTCWLQLSPF LgiWntA ISEDGL--MNVWNNGAGRK---------MVKDELELMCKCHGV-SGSCSVKICWRKMKSF PduWnt1 RDLRYM--MNLHNNQAGRI---------HVVSEQHQECKCHGM-SGSCTVKTCWMRLAPF PduWnt10 -------------------------------------------------------AAPQF PduWnt11 RSKRHL--VNSHNNAAGRK---------LISDSLQTACKCHGV-SGSCSIKTCWKALPDL PduWnt16 SDIRSL--VNLQNNQVGRE---------AIAKQLHLRCRCHGV-SGSCAVKSCWKTMPNF PduWnt2 RDARAL--MNLHNNRAGRR---------AVKKFMKLQCKCHGV-SGSCTIRTCWLAMQDF PduWnt4 SSSRVL--MNLHNNEAGRK---------IIEENMLTQCKCHGV-SGSCELKTCWRAMPSF PduWnt5 GLARTL--MNVHNNEAGRR---------AVFMHSKVACKCHGV-SGSCSLKTCWNQLPSF PduWnt6 NDITTL--VRMHNNKAGRL---------AVRNHVRKVCKCHGL-SGSCTLETCWLKMPRI 'PduWnt7 - wnt7 CDS' EDSRSL--MNLHNNRAGRK---------ALKDLMARDCKCHGV-SGSCTLRTCWRTLPSF PduWnt8 KDARAI--VHLHNNDVGRI---------SIRRNLKLVCKCHGV-SGSCTTKTCWQQLAGF 'PduWnt9/14/15' ------------------------------------TCKCHGV-SGSCTTQTCWHTLSEF PduWntA EDPDGL--MNIWNNGAGRK---------TIKSSMRLLCKCYGVFSGSCSVKICWRTMAPF PvuWnt1 RDFRYM--MNLHNNEAGRV---------HVSTGMNQECKCHGM-SGSCTIKTCWMRLPTF PvuWnt10 KDIHSQ--INLHNNRAGRL---------AVIRHVKKLCKCHGM-SGSCELKTCWKAAPDF PvuWnt2 RDARAL--MNLHNNRAGRR---------AVKRFRKLECKCHGV-SGSCTVRACWLAMQEF PvuWntA LNADGL--MNVWNNGAGRK---------TVKEELDLICKCHGV-SGSCSVKICWRKMKTF SmaWnt1 ----------------------------MVINKMEVQCKCHGV-SGSCEMRTCWRSLPKF SmaWnt11 -----------------------------MEANQKLVCKCHGV-SGSCAQRVCFRQLRRI SmaWnt11b RKKSLLRSLNRHNYLAGVV---------LMEANQKLVCKCHGV-SGSCAQRVCFRQLRRI 'SmaWnt2(d)' EHPRTL--MNLHNKKAGRR---------LIWKNRITKCKCHGV-SGACSMRTCWQRVNEF 'SmaWnt4(d)' NAKLGL--TNLHNNYVGRH---------MVINKMEVQCKCHGV-SGSCEMRTCWRSLPKF SmaWnt5 ELARML--MNLHNNRAGRL---------AVYKLASVACKCHGV-SGSCSLRTCWTQLSPF SmeWnt1 WNKKTL--MNLHNTGTGRR---------VAVKSMNVKCVCQGT-SGSCTTKICHRKVASI SmeWnt11a NKSQIIKRLNGHNYEVGIM---------IMMNSWKSKCKCHGV-SGSCINKICFRQLRRL SmeWnt11b KKLKKIQRLNGHNYEAGLR---------IQLDNQKIHCKCHGV-SGGCNQRICYRQVRRL SmeWnt2b QTGQAL--MNQHNNRVGRR---------VVWKTRLKKCKCHGV-SGACSLRTCWQRMNDF SmeWnt4 NPSVGL--VNLHNSHAGTK---------IVIDNMMMKCKCHGV-SGSCETKTCYRALPDL 'SmeWnt4.' QTSAAL--TNMHNNHVGRE---------SVINKMIVKCKCHGV-SGSCEMRTCSRNLPSF 'SmeWnt4..' KPEKAL--TKLHNNHVGRQ---------AVIMKMAKKCKCHGV-SGSCEMKTCIRALPDF SmeWnt5 DLANIM--VNLHNNNAGRM---------AVYKMSSVACKCHGV-SGSCSLRSCWKQLPPF SmeWntP-4 SAFKIF--LELYNNHVARN---------VIIKSMETKCKCQGA-SGACTSKYCWKTLPDF CteWnt1 -GR-VGKVVKDRF-DGASQ-VEQ------------------------------------- CteWnt10 -RK-VGSIIKQKF-EQATK-VDT------------------------------------- CteWnt11 -RT-VGTKIQERY-RLAVEVVNK------------------------------------- CteWnt16 -RE-AGNELKQKY-ENSIS-IAE------------------------------------- CteWnt2 -SR-VGSYLKTRY-DSAKQ-VSM------------------------------------- CteWnt4 -RE-VGAMLKDRF-DGASE-VEE------------------------------------- CteWnt5 -RG-TGNRIKDAY-DRGTE-VAF------------------------------------- CteWnt6 -RD-VGDRLKERF-DGAYK-VSI------------------------------------- CteWnt7 -RS-IGDHLKQKF-TKAKQ-VVP------------------------------------- CteWnt8 -RS-VGTFLKRCY-ARAID-VDF------------------------------------- CteWnt9 -HE-VGSDLKSKY-DSAVKVVVS------------------------------------- CteWntA -RN-IGSQLKDKF-DGASR-VIH------------------------------------- EgrWnt1 -RV-IGNQLKVKY-EQASQ-VMRGVTGFSNLDNTLPVSWGHHGRSSPIVHLN-------- EgrWnt11a DTEPIKAALRQRYLVGCLQ-VFF------------------------------------- EgrWnt11b DSAQLQDIILQRY-------MV-------------------------------------- 'EgrWnt2/10' -RV-IGNQLK-------------------------------------------------- EgrWnt4 -RS-VGTQLRELF-QEAVM-VDY------------------------------------- EgrWnt5 -PR-VGQRLQERY-ESAIK-VSSVDTIIVAFTIPISAYILW------------------- 'EmuWnt1.ORF' -RV-IGNQLKVKY-EQASQ-VMRGVTGFSNLDNTLPVSWGHHGRSSPIVHLN-------- 'EmuWnt11.1' DTEPIKAALRQRYLVGCLQ-VFFKFISLQQTFLYWM------------------------ 'EmuWnt11.2' DSAQLQNIILQRY-------MV-------------------------------------- 'EmuWnt2/5/8/10.ORF' -RG-VGDLLKKAY-SNALQ-VSF------------------------------------- EmuWnt4 -RS-VGTQLRELF-QEAVM-VDY------------------------------------- EmuWnt5 -PR-VGQRLQERY-ESAIK-VSSVDTIIVAFTIPVSAYILW------------------- HmiWnt1 -RT-IGN---EGYHGRGNS-IVHLN----------------------------------- HmiWnt11a DTEPIKAAIKQRYLATAKM-VSG------------------------------------- HmiWnt11b DSSQLQDIILQRY-MMARY-VSV------------------------------------- HmiWnt2 -KN-KSRRKKQRS----------------------------------------------- HmiWnt4 -RS-VGNQLQDLF-QKAVM-VDY------------------------------------- HmiWnt5 -PR-VGQRLQERY-ESAIRVVKF------------------------------------- HroWnt1 -SL-VAAILKEKF-NGATK-VDQ------------------------------------- HroWnt10 -RR-VADVIKTKF-KMAVR-V--------------------------------------- HroWnt11a -KV-VAVMLQNRY-SAAVE-M--------------------------------------- HroWnt11b GDR-LLHVLVKKY-YQAIR-VR-------------------------------------- HroWnt11C -KT-IGALLVHQY-AIAVE-VDLRRPRVKNNDVTAGGKRGGRSGDKQQQQISNSFWLDHE HroWnt16a -RE-VAHALKNKY-ETSIE-ISI------------------------------------- HroWnt16b -RQ-VGDQLKFKYLDSVEISPSL------------------------------------- HroWnt2 -SE-IAEFLMSKY-NSAKH-VYI------------------------------------- HroWnt4 -DD-VSKRLKINY-DNSKM-VKH------------------------------------- HroWnt5a -NE-IARELKFKY-ENLPHLVKF------------------------------------- HroWnt5b -RQ-TGDRLRDRY-DAAAQ-VT-------------------------------------- HroWnt6 -AT-VGKKLRKVY-EKAVQ-VTA------------------------------------- HroWnt7 -KT-IGSKLMKTY-ERARQ-VEP------------------------------------- LgiWnt1 -RN-IGHILKDRF-DGASK-VLP------------------------------------- LgiWnt10 -RA-VGTILKKKY-DRATK-VDI------------------------------------- LgiWnt11 -DS-IGATLKNRY-ALAVE-VKR------------------------------------- LgiWnt16 -RK-VGLELKDKY-EKSVR-LAR------------------------------------- LgiWnt2 -RR-VGDFLKRKY-NGATQ-IMM------------------------------------- LgiWnt4 -KK-VGEILKEKF-DGATE-VKH------------------------------------- LgiWnt5 -RE-IGNRLKDRY-DASTE-VKF------------------------------------- LgiWnt6 -RD-VGNRLKQKF-DGGSK-VIS------------------------------------- LgiWnt7 -RK-IGDSLKKRY-KKSKI-VVP------------------------------------- LgiWnt9 -SK-IGRTLKNKY-ERAKK-VLI------------------------------------- LgiWntA -RA-IGSALKGRF-DGASL-VKM------------------------------------- PduWnt1 -RQ-TGARLKDRF-DGASR-VYQ------------------------------------- PduWnt10 -HV-VGEVLKQKY-LQASK-MIN------------------------------------- PduWnt11 -KE-LGMMLQKKY-AIAVE-VDLKEIFL-------------------------------- PduWnt16 -NE-VGKFLKKRY-EKPTE-IAP------------------------------------- PduWnt2 -RR-VGAFLKSKY-NGAVR----------------------------------------- PduWnt4 -RK-IGYMLKEKF-DGACE-VQQ------------------------------------- PduWnt5 -RE-VGDRLKDKY-DGATE-VKF------------------------------------- PduWnt6 -HS-IGRHLKQKF-DGATM-MFG------------------------------------- 'PduWnt7 - wnt7 CDS' -RS-IGASLMRRY-NRARQ-VMP------------------------------------- PduWnt8 -KE-VGIYLRRKYRRRALK-VDF------------------------------------- 'PduWnt9/14/15' -EE-IGKILKMKY-RNAVR-YPP------------------------------------- PduWntA -RE-IGRHLKQKF-DGASL-VTI------------------------------------- PvuWnt1 -RT-VGNLLKDRF-DGASR-VLPGNDGNSILDK--------------------------- PvuWnt10 -RA-VGAILKRKY-EAATQ-VDI------------------------------------- PvuWnt2 -RR-VGDYLKLKY-NGATQ-IMI------------------------------------- PvuWntA -RA-IGTTLKNRF-DGASL-VKM------------------------------------- SmaWnt1 -RN-LGAQLQERF-HEAIQ-VTYMQNRLVPMKALEQL----------------------- SmaWnt11 DTEIMQKALKMRYLVSLNK-ILAINVIFLN------------------------------ SmaWnt11b DTEIMQKALKMRY-LAAKQ-VSE------------------------------------- 'SmaWnt2(d)' -RL-IGMMLKAAY-DSAIH-VTYEPRIDQLKRISNRINSNQNNN---------------- 'SmaWnt4(d)' -RN-LGAQLQERF-HEAIQ-VTY------------------------------------- SmaWnt5 -TR-IGRYLRQGY-DEAIK-VKF------------------------------------- SmeWnt1 -DE-IGNILKEKY-ENAVKVVKE------------------------------------- SmeWnt11a DDEELLKMIKDYY-LRAKH-VTM------------------------------------- SmeWnt11b DDDVLLNVLRKQY-LSAKY-VDI------------------------------------- SmeWnt2b -RR-IGDMLKKLY-NKPQK-VTY------------------------------------- SmeWnt4 -RK-VGDILKEKF-SKAIL-VRM------------------------------------- 'SmeWnt4.' -RV-VGDQLKERF-RKIIQ-VDF------------------------------------- 'SmeWnt4..' -RV-VGDLLKSRF-HKAMQ-VHF------------------------------------- SmeWnt5 -IQ-IGHHMTQKY-DMAKQ-VRF------------------------------------- SmeWntP-4 -SK-IGEALKNKY-LNAKK-LPR------------------------------------- CteWnt1 ------------------------------------------------------------ CteWnt10 ------------------------------------------------------------ CteWnt11 ------------------------------------------------------------ CteWnt16 ------------------------------------------------------------ CteWnt2 ------------------------------------------------------------ CteWnt4 ------------------------------------------------------------ CteWnt5 ------------------------------------------------------------ CteWnt6 ------------------------------------------------------------ CteWnt7 ------------------------------------------------------------ CteWnt8 ------------------------------------------------------------ CteWnt9 ------------------------------------------------------------ CteWntA ------------------------------------------------------------ EgrWnt1 ------------------------------------------------------------ EgrWnt11a ------------------------------------------------------------ EgrWnt11b ------------------------------------------------------------ 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ------------------------------------------------------------ EgrWnt5 ------------------------------------------------------------ 'EmuWnt1.ORF' ------------------------------------------------------------ 'EmuWnt11.1' ------------------------------------------------------------ 'EmuWnt11.2' ------------------------------------------------------------ 'EmuWnt2/5/8/10.ORF' ------------------------------------------------------------ EmuWnt4 ------------------------------------------------------------ EmuWnt5 ------------------------------------------------------------ HmiWnt1 ------------------------------------------------------------ HmiWnt11a ------------------------------------------------------------ HmiWnt11b ------------------------------------------------------------ HmiWnt2 ------------------------------------------------------------ HmiWnt4 ------------------------------------------------------------ HmiWnt5 ------------------------------------------------------------ HroWnt1 ------------------------------------------------------------ HroWnt10 ------------------------------------------------------------ HroWnt11a ------------------------------------------------------------ HroWnt11b ------------------------------------------------------------ HroWnt11C EKWIDFDYGGEEALIMAMNNNNNNNNNNQNGINNNNANNANNNHMNNDYNEYDYGVDVRV HroWnt16a ------------------------------------------------------------ HroWnt16b ------------------------------------------------------------ HroWnt2 ------------------------------------------------------------ HroWnt4 ------------------------------------------------------------ HroWnt5a ------------------------------------------------------------ HroWnt5b ------------------------------------------------------------ HroWnt6 ------------------------------------------------------------ HroWnt7 ------------------------------------------------------------ LgiWnt1 ------------------------------------------------------------ LgiWnt10 ------------------------------------------------------------ LgiWnt11 ------------------------------------------------------------ LgiWnt16 ------------------------------------------------------------ LgiWnt2 ------------------------------------------------------------ LgiWnt4 ------------------------------------------------------------ LgiWnt5 ------------------------------------------------------------ LgiWnt6 ------------------------------------------------------------ LgiWnt7 ------------------------------------------------------------ LgiWnt9 ------------------------------------------------------------ LgiWntA ------------------------------------------------------------ PduWnt1 ------------------------------------------------------------ PduWnt10 ------------------------------------------------------------ PduWnt11 ------------------------------------------------------------ PduWnt16 ------------------------------------------------------------ PduWnt2 ------------------------------------------------------------ PduWnt4 ------------------------------------------------------------ PduWnt5 ------------------------------------------------------------ PduWnt6 ------------------------------------------------------------ 'PduWnt7 - wnt7 CDS' ------------------------------------------------------------ PduWnt8 ------------------------------------------------------------ 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA ------------------------------------------------------------ PvuWnt1 ------------------------------------------------------------ PvuWnt10 ------------------------------------------------------------ PvuWnt2 ------------------------------------------------------------ PvuWntA ------------------------------------------------------------ SmaWnt1 ------------------------------------------------------------ SmaWnt11 ------------------------------------------------------------ SmaWnt11b ------------------------------------------------------------ 'SmaWnt2(d)' ------------------------------------------------------------ 'SmaWnt4(d)' ------------------------------------------------------------ SmaWnt5 ------------------------------------------------------------ SmeWnt1 ------------------------------------------------------------ SmeWnt11a ------------------------------------------------------------ SmeWnt11b ------------------------------------------------------------ SmeWnt2b ------------------------------------------------------------ SmeWnt4 ------------------------------------------------------------ 'SmeWnt4.' ------------------------------------------------------------ 'SmeWnt4..' ------------------------------------------------------------ SmeWnt5 ------------------------------------------------------------ SmeWntP-4 ------------------------------------------------------------ CteWnt1 --------------------GNGAINRSKNRFNLIPI----------------------- CteWnt10 --------------------DNSSKRSRRLKTA--------------------------- CteWnt11 --------------------KVKNSKERRFVPL--------------------------- CteWnt16 --------------------KSKRKLRQRQRRQ--------------------------- CteWnt2 --------------------NPMGTGLIATT----------------------------- CteWnt4 --------------------QKVGSRKKLVPK---------------------------- CteWnt5 --------------------NRQGTRLVQT------------------------------ CteWnt6 --------------------ANDGRNIIPIED---------------------------- CteWnt7 --------------------LQSSRTRNPEFLHLKRL----------------------- CteWnt8 --------------------QNGALQQTATRRHR-------------------------- CteWnt9 --------------------ANQSTGKGQLTKRRK------------------------- CteWntA --------------------HDKKHRLKPM------------------------------ EgrWnt1 --------------------RWNNQRILREVDHDSLLYQGGSTSRPPSLLKVSFDR---- EgrWnt11a ------------------------------------------------------------ EgrWnt11b ------------------------------------------------------------ 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ---------------------VNNRLVPKSALYHRPSPSGPPQPSPSAQSSVPVGAS--- EgrWnt5 --------------------SCYSQFVGRHVTLSQVKFNRRGTQLRRA------------ 'EmuWnt1.ORF' --------------------RWNNQRILREVDHDSLLYQGGSTSRPPSLLKVSFNR---- 'EmuWnt11.1' --------------------SFYYYHEDDPSICQFFGFPTTSPAKMVSGIADGNLMASVF 'EmuWnt11.2' ------------------------------------------------------------ 'EmuWnt2/5/8/10.ORF' --------------------DAATRQLRRLA----------------------------- EmuWnt4 ---------------------VNNRLVPKSALYHRSSPSGPPQPSPLAQSSVPVGAS--- EmuWnt5 --------------------LCYSQFVGRHVTLSQVKFNRRGTQLRRA------------ HmiWnt1 --------------------RWNNQRTLREVSHDSLLYRGGSSPRPSLLKVTFDR----- HmiWnt11a --------------------IQNDRLMVSVFKET-------------------------- HmiWnt11b --------------------DYGNLLIAKEYEYG-------------------------- HmiWnt2 ------------------------------------------------------------ HmiWnt4 ---------------------VNNRLVPKSALYNHRLPPPGHPPQPQPSSGAPIPINIGG HmiWnt5 --------------------NRLGTRLRRA------------------------------ HroWnt1 --------------------GNSHHEHEKRRLLPH------------------------- HroWnt10 ------------------------------------------------------------ HroWnt11a --------------------GDNAARISALQTTGSKKSSR-------------------- HroWnt11b --------------------GSKNINSMMIKHKNRNYNNNNNNNNNNNNNNNNNNNNNNN HroWnt11C MKAKSAPPSPPSSSNKKNNKNNKNKNNKNKKDVKKXLVPIL------------------- HroWnt16a ------------------------------------------------------------ HroWnt16b --------------------QLADSNSVSVASGQKSQW---------------------- HroWnt2 --------------------DTNNLISHYHTSLSRIKRNKKPKPFKLSMI---------- HroWnt4 ------------------------------------------------------------ HroWnt5a --------------------NNGGTNSDYENIDNDDNTQQQPAT---------------- HroWnt5b ------------------------------------------------------------ HroWnt6 --------------------SNDHDQD--------------------------------- HroWnt7 --------------------IRGQRSLSAVMLKLKRSA---------------------- LgiWnt1 --------------------GNTGRAVKRKRRRFNFSPV--------------------- LgiWnt10 --------------------TNSANTKLI------------------------------- LgiWnt11 --------------------KRKKKQKVLVPI---------------------------- LgiWnt16 --------------------RSRKRLRRKDK----------------------------- LgiWnt2 --------------------NQAGTGLIVA------------------------------ LgiWnt4 --------------------QVKGTRNELVPL---------------------------- LgiWnt5 --------------------NKRGTKLTRK------------------------------ LgiWnt6 --------------------SNDGKYLIPE------------------------------ LgiWnt7 --------------------YLGRRARTAVT-----LILKRA------------------ LgiWnt9 --------------------QTNQATGKNLLVRRANAETNAL------------------ LgiWntA --------------------DRRRKRLKRT------------------------------ PduWnt1 --------------------GNSGNSRNRNRLQKFNLLPV-------------------- PduWnt10 --------------------TNSASGRVRLRLVYK------------------------- PduWnt11 --------------------QVNKKRMRGSRERRLVAVHR-------------------- PduWnt16 --------------------RSKKRLRRREK----------------------------- PduWnt2 ------------------------------------------------------------ PduWnt4 --------------------KKAGSRSVLVPR---------------------------- PduWnt5 --------------------NRAGTRLVQA------------------------------ PduWnt6 --------------------SNDGKSLIP------------------------------- 'PduWnt7 - wnt7 CDS' --------------------IKGRRARTPIFLKLKKA----------------------- PduWnt8 --------------------HNGALRRTKSNRR--------------------------- 'PduWnt9/14/15' --------------------GGSHNNAGEQQLSLR------------------------- PduWntA --------------------NSKKSKLKPV------------------------------ PvuWnt1 --------------------GNAGRAVGRKKRRFNFSPV--------------------- PvuWnt10 --------------------SNSPMPSVK------------------------------- PvuWnt2 --------------------NQAGTGLIVA------------------------------ PvuWntA --------------------DKRKKRLKRL------------------------------ SmaWnt1 --------------------NKESNGNALLLSHPALLSSTGATMSSRVSRNTLDSLTSST SmaWnt11 --------------------KFSEGGFVKILVILYSAKQVSEGKNGELIAKTFIGN---- SmaWnt11b --------------------GKNGELIAKTFIGN-------------------------- 'SmaWnt2(d)' --------------------YMTRRNLPVVSPNRNHDSRNCSKDDWNDYSNNGRLQRRWP 'SmaWnt4(d)' --------------------MQNHSLTSSTSLS--------------------------- SmaWnt5 --------------------NRRGTRLRRA------------------------------ SmeWnt1 --------------------DSEVNLLANSQKRKTTNKNQQYRKALIIARKHIFI----- SmeWnt11a --------------------EDDNKLYPTHFITT-------------------------- SmeWnt11b --------------------LSDDSLVAADPFGGS------------------------- SmeWnt2b --------------------NPFQKSLTFS------------------------------ SmeWnt4 ----------------------NDFKLVPMH----------------------------- 'SmeWnt4.' ---------------------FDNKLIPKYP----------------------------- 'SmeWnt4..' ---------------------VDSRLIPRYW----------------------------- SmeWnt5 --------------------NRKGTHLRKI------------------------------ SmeWntP-4 --------------------ILKKRIRKNLSMGEDISL---------------------- CteWnt1 ---NTNHKPPEPKDLVYFERSPT--FCTKDPSIGHTGTHGRPC-NASS-------IGVEG CteWnt10 ---RRRKRHIDNTDLVYFERSPN--FCEPDKTLDSPGTVGRVC-NSSS-------LHIDS CteWnt11 ---MDKKTSFSENELIYYTKSPD--YCLPDGGLGSMGTRGREC-EKTN-------DGSIG CteWnt16 ---RQRRTSNNGLDMVYIEDSPN--YCRKNMKRGILGTKGREC-ERDP-------DARDS CteWnt2 ---SGGRKKTTRSDIVFFDESPD--YCVQDPLAGSLGTADREC-NHTS-------KGPHG CteWnt4 ---NTQFKPHETQDLVYLEASPD--YCISDPETGSLGTSGRTC-NRSS-------KAIDG CteWnt5 ---NKRFNKPTKEDLLYLAESPD--YCEADPGIGSLGTQGRQC-NKHS-------QGMDG CteWnt6 ---HDAARRPSGENLVYLDESPS--FCKPSRKQGSLGTLDRLC-NPDT-------STTDS CteWnt7 ---KSLHRKPRKADLVYLKRSPS--YCEKDEGIGSLGTTGRLC-NRTA-------NSYNN CteWnt8 ---RDRSELIRKTDLVYLQTSPD--YCRVN---GSYATLGRQCVRSSA-----AAKSGRR CteWnt9 ---NSVQSNPKKGDLVFLEKSPN--YCEPTAFGH--GTTGRVCDLNKN------------ CteWntA ---DRYQKKPNKKDLVYLQESPD--FCSSNTTIGSLGTQGRAC-NKTS-------YGLDG EgrWnt1 ---SGRDQKPTTQELVFYEQPANNLFCEPNPNLHILGTRGRTC-NSTS-------SASDS EgrWnt11a ------KFISLQQTFLYWMSCYY--YHEDDPSICQF------------------------ EgrWnt11b -------------------------YCSTN--------------DTER-------TQSNH 'EgrWnt2/10' -------------ELVFYEQPANNLFCEPNPNLHILGTRGRTC-NSTS-------SASDS EgrWnt4 ---LAGLPMLKENELIYTTRSPS--YCHHDPRFGSIGTYGRRC-SVDS-------KGPDN EgrWnt5 ---NRHLRQITSDHLIYLEESPN--FCAVNPLTGRTLTSGREC-RLQG-------HANER 'EmuWnt1.ORF' ---SGRDQKPTTQELVFYEQPANNLFCEPNSNLHILGTRGRTC-NSTS-------SASDS 'EmuWnt11.1' KETDFVDEYVQLEDLVFTQHSPD--YCDPDPQRGSLGTHG-------------------- 'EmuWnt11.2' -------------------------YCSTN--------------DTER-------TQSNH 'EmuWnt2/5/8/10.ORF' -------------DPLYFGGMPL--------------PAGHLMKRSTS-----WFVGSNG EmuWnt4 ---LAGLPMLKENELIYTTRSPS--YCHHDPRFGSIGTYGRRC-NADS-------KGPDN EmuWnt5 ---NRHLRQITSDHLIYLEESPN--FCAVNPLTGRTLTSGREC-RLQG-------HANER HmiWnt1 ---SGRDLKPTTKELVFYEQPTKELFCNANPNLHILGTKGRTC-NSTS-------TGPEN HmiWnt11a ---DFEDEYAQLEDLVVTQHSPD--YCDPDPERGSLGTQG--C-SLNA-------TGDGR HmiWnt11b ---SYTPRVIHYSELAFTEHSPD--FCEPDAQLGSVGTKGFCSTNVTE------RAQSNH HmiWnt2 ---------------------------KHNLNGGE---------NDTI-------IDVDD HmiWnt4 ---ILGLPMPKENELIYTTRSPS--YCHHDPRYGSIGTYGRRC-SVDS-------KGPDN HmiWnt5 ---NRNLRQITPDHLIYLEDSPN--FCAVNPLTGKTMMSGREC-LLEG-------HSSER HroWnt1 ---NPEHKKPTKFDLVYYEDSPT--FCDPDPSLGYPGVKGRKC-IENS-------MGMDG HroWnt10 ------------------------------------------------------------ HroWnt11a ---SLSKRVASTDRLVFSSISPD--YCLPDPSVRSVGTQGREC-DKDS-------TGSSA HroWnt11b GRMISSSQESFSNNLIYSAISSD--YCLPDKYLGSSGTYGREC-HLEP-------KKQGH HroWnt11C ----PFRKNFSENDLLFITKSPD--YCLPEPSLGSIGTKGREC-SRTE-------D---- HroWnt16a ----------SSADLIFLKKSPD--YCKQNLKKGIPGTRGRLC-NKNS-------TGPDG HroWnt16b ---RSIPQPASDTDLIFLDKSPN--YCRPDRKRGVQGTRDRNC-QPDT-------DKPNN HroWnt2 ---DRKLKRPAKDDLVYVDFSPD--YCQTNHELG----------RQEY------------ HroWnt4 --------SFNETDLLFTHASPS--YCDLDLSRGSLGTSGKLCSNDKT-------ATTDS HroWnt5a ---DTSSNRPTRDTLIYTEPSAD--FCEALTNTSWPGTHGRQC-KRGE-------PGSEG HroWnt5b -------NGPTKDDLIFTEPSPN--FCNPDPERGSLGTSGRVC-DRRS-------QGTSG HroWnt6 ---GESMLMTMPRSLVYSVKNLD--FCTRNVKKGIEGTQGRIC-NPPV-------TKIGS HroWnt7 ---SKTEKKPSYRELVYLGESPD--YCKKNRTIGVLGTKGRQC-DRNG-------DGLEN LgiWnt1 ---NPNHKRPGRRDLVYFEHSPT--FCEKENMIGFEGTAGREC-NSTS-------LGVNG LgiWnt10 ---KRNGRIPKHLELLFYEKSPN--FCDPNPLVDSPGTTGRLC-NKTS-------GGINN LgiWnt11 ---MKNKKTIRSDELIYYTKSPD--YCSPDAKSGSIGTHNRLC-DKTS-------RGSGG LgiWnt16 ---TKRKQGISKQELVFVHRSPN--YCKEDIKRGIFGTRGRVC-NRSS-------PTEES LgiWnt2 ---NKNHKHPTRSDLVYFESSPD--YCIKDEESGSLGTEGREC-IKGS-------LGTGG LgiWnt4 ---NPQFKRHTESDLVYMVASPD--FCEADKKTGSLGTHGRIC-NKTS-------KAIDG LgiWnt5 ---VKKWNKYTKNDIIFLDDSPD--YCDKNAETGSVGTAGREC-DRNS-------QGLGG LgiWnt6 ---GDTIKPPSKEDLVYSEESPD--FCRRNKKEGALGTRGREC-DPTS-------MGVGG LgiWnt7 ---KRPHRKPRRSHLVYLDKSPN--YCDFDGKTGSLGTVGRKC-NRTT-------KDTDG LgiWnt9 ---NNEGRSPKRGNLLYMDESPS--FCRRSRY--TPGTTGRTCDKDRD------------ LgiWntA ---NKLQKRPTKKDLVYLNESPD--FCEHNLENGSVGTRGREC-NKTS-------YGLDG PduWnt1 ---NPNHKSPGPQDLVYFEESPT--FCDENRTLGLQGTTGRQC-NASS-------IGVDG PduWnt10 ---KKRRKRPSKSSLVFYETSPN--FCEDSSWLDSPGTRG-------------------- PduWnt11 ---PDKRKDFQAEELIYYTKSPD--YCLPDTTLGSLGTRGREC-NKDS-------TSSGG PduWnt16 ---LFRKVPIKGDELVYLDPSPN--YCRQNPDKGIMGTRGREC-KKDS-------KGPDS PduWnt2 ---------------VMMNQEGN------------------------------------- PduWnt4 ---STQYKPHSSTDLVYLVASPD--FCERDPKTGALGTHGRRC-NKTS-------KAIDG PduWnt5 ---DKKYNRPTKEDLLYLSLSPD--YCLANDKTGSMGTTGRFC-NKTS-------PGMDG PduWnt6 ---SGTSTPPDGEDLVYTTQSPD--FCRVDKKQGSLGTHGRRC-NPKS-------KALDG 'PduWnt7 - wnt7 CDS' ---RRPNKKPRRADLVYLRHSPN--YCENDPLTGSLGTRGRQC-NRTS-------TGTDG PduWnt8 ---HSQLPTVKKGDLVYLAKSGN--YCSLNGSAATYATLGRQC-SRPK-------KGDTK 'PduWnt9/14/15' ---KRRRLGPRKRDLLFLEDSIN--FCDSSDF--SPGTKGRECNSKRK------------ PduWntA ---DRRIKKPAKDELVYMEDSPD--YCEYDPGIGSLGTRGRQC-NKTS-------YGLDG PvuWnt1 ---NPNHKRPGRRDLVYFENSPT--FCEKENVIGFEGTSGREC-NATS-------LGVQG PvuWnt10 ----RNGRRPKHLELLFYEKSPN--FCDPNPVVDSPGTTGRLC-NKTS-------IGIDN PvuWnt2 ---NRNHKRPTRSDLVYFETSPD--YCIKDIEIGSLGTAGRVC-KKGS-------LGTDG PvuWntA ---SRLQKRPTKKDLVYLQESPD--FCEHNLEFGSLGTRGRQC-NKTS-------YGLDG SmaWnt1 SLSPSSLPSPTENDLIYISESPT--FCHHDPRYGSIGTYGRQC-DENS-------QGLNS SmaWnt11 ---GFIDEVVKPGELVFSEHSPD--YCNVEPQRGSVGT------RTSN------------ SmaWnt11b ---GFIDEVVKPGELVFSEHSPD--YCNVEPQRGSVGTRDRIC-TLKD-------TGTSN 'SmaWnt2(d)' RTVMTKSKEIPKNQLVYLEESPN--YCFFDETIGHLGIAGRQCNATSK-------DAINS 'SmaWnt4(d)' ---PSSLPSPTENDLIYISESPT--FCHHDPRYGSIGTYGRQC-DENS-------QGLNS SmaWnt5 ---SRQLSRITPDHITYLDESSN--YCDYDSNTQTSSTRGREC-LPNN-------TDQAS SmeWnt1 ---RTEKQYPYARDLVYLEDVPKNFYCDSKPEWHILGTTGRVC-NSLS-------NSTDS SmeWnt11a ---GLQKEPLKTTDLAFIEHSSD--YCEPDPSAGSIGTQGRQCETVNV-----TLSKTNH SmeWnt11b ---EERPKPISQTDLVFTEHSPD--FCEPDPTTGSVGTHGRVCKTENT-----SKTSTEH SmeWnt2b ---KNRFRRPSKKKLVYIDNSQD--YCIQDPSIGHPGTGGREC-NYTS-------SQHDS SmeWnt4 ----SGESRITEHDLTYLKRSPN--FCYHNPSYGSLGTQGRLC-NNTQVLEHEFVEGS-- 'SmeWnt4.' -----SKEMFAEVDMLYLNDSPD--HCHHDFGKGTLGTNGRICNDTYN---NTYQEPENS 'SmeWnt4..' -----PSRMFTDNDLIYLLKSPN--YCVHNPHFGSLGTQGRKC-AEMSLLEKKPEETRGS SmeWnt5 ---SGHRKKLQPDELIYYKNSPD--YCELSRVHSGFITSGREC-KLDR-------KKSER SmeWntP-4 ---VINDPFIEEDQLMFLRPSFD--YCFPNMKLGIKGVNGREC-EDVA-------SGPTS CteWnt1 --------CDLLC--CGRGYRSE-LYTARERCNCIFHWCCKVTCDTCTKTK--------- CteWnt10 --------CDTLC--CGRGYNTV-RLTKIERCQCKFRWCCDVLCKKCLMTS--------- CteWnt11 --------CQSMC--CGRGFTSQ-VVEVKHRCECKYFYCCYVECKTCTKKV--------- CteWnt16 --------CNTLC--CGRGYNTE-VVRFVERCQCKFVWCCEVKCKICETIT--------- CteWnt2 --------CDVMC--CGRGYDTH-VVRRMRKCDCKFHWCCYVKCRECEELV--------- CteWnt4 --------CELMC--CGRGFNVK-RRVVDERCHCKFHWCCYVKCQQCKKVV--------- CteWnt5 --------CNLMC--CGRGYNTY-KAKVSERCQCKFHWCCYVQCKTCERVV--------- CteWnt6 --------CDIMC--CGRGYRSY-KVVVQENCRCQFKWCCKVICQTCSRTL--------- CteWnt7 --------CDLMC--CGRGYNTH-QYTRTWQCDCKFHWCCHVTCDECTELT--------- CteWnt8 NRHPERKSCHRLCKACGLKVTDK-VVEVTSSCKCKFKWCCEVACQQCRRKV--------- CteWnt9 --------CDILC--CGRGYNIH-TRIVDKPCHCQVIWCCHVKCQRCSVRE--------- CteWntA --------CSLMC--CGRGYQTT-LITVVEDCNCKFVWCCNVVCDECIKRE--------- EgrWnt1 --------CRLLC--CERGHRTK-HYYALENCECKFVWCCRVECQKCLVLK--------- EgrWnt11a --------CMNMC--CGRGHKST-THQIYEKCNCIMQPNFKVHCQTCIRNE--------- EgrWnt11b --------CQNMC--CGRGYVTY-EETTFTNCNCRITRDFRVICDKCPRIV--------- 'EgrWnt2/10' --------CRLLC--CERGHRTK-HYYALENCECKFVWCCRVECQKC------------- EgrWnt4 --------CNFLC--CGRDYRRE-VFIQQEKCKCKFHWCCEVRCETCEKTV--------- EgrWnt5 --------CTVLC--CGRGHRTY-TREVQERCYCQFHWCCSVECQTCSRRE--------- 'EmuWnt1.ORF' --------CRLLC--CGRGHRTK-HYYALENCECKFVWCCRVECQKCLVLK--------- 'EmuWnt11.1' --------CVNMC--CGRGHKST-THQIYEKCNCIMQPNFKVHCQTCIRNE--------- 'EmuWnt11.2' --------CQNMC--CGRGYVTY-EETTFTNCNCRITRDFRVICDKCPRIV--------- 'EmuWnt2/5/8/10.ORF' --------GNLLAWQRRRRETQFGEKWIKRQKDKLVYLDYSPDYCKADHRI--------- EmuWnt4 --------CNFLC--CGRDYRRE-VFIQQEKCKCKFHWCCEVRCETCEKTV--------- EmuWnt5 --------CTVLC--CGRGHRTY-TREVRERCYCQFHWCCSVECQTCSRRE--------- HmiWnt1 --------CNSLC--CGRGYRTR-HYYALENCECKFVWCCRVECQKCLVLKRFETINTLA HmiWnt11a --------CAIMC--CGRGHKST-THQIYEKCNCIMQPNFKVHCQTCIRNE--------- HmiWnt11b --------CQNMC--CGRGHVTF-EETKFTNCNCRITKDFRVICDKCPQVV--------- HmiWnt2 --------SRIL------------MDIHNQKVGRRFVWQSREK----------------- HmiWnt4 --------CETLC--CGRDYRRE-VFIQQEKCKCKFHWCCEVRCETCEKTV--------- HmiWnt5 --------CSHLC--CGRGHRTF-TREVPDRCFCQFHWCCSIECQTCIRKE--------- HroWnt1 --------CDVMC--CGRGYKKV-TVREVQKCNCSFVWCCDVTCDYCDVVE--------- HroWnt10 ------------------------------------------------------------ HroWnt11a --------CRSMC--CGRGYVSE-IVVQTFKCNCKYYWCCEVKCKVCRKLV--------- HroWnt11b --------CDVMC--CGRGFRNE-TRSRGVKCHCKYYWCCYVKCKTCVQDV--------- HroWnt11C ------------------------------------------------------------ HroWnt16a --------CDYLC--CGRGFNLA-ETRLVERCHCKFIWCCSVQCKMCERVE--------- HroWnt16b --------CKHLC--CGRGYRTR-VIEVDEACECQFMWCCSIQCKICKKVQ--------- HroWnt2 ------------------------------------------------------------ HroWnt4 --------CKVLC--CGRGYVVVGEVTLVEKCHCKFHWCCRVECQECKRRV--------- HroWnt5a --------CDLMC--CGRGYNTF-REKVTEGCRCHFVWCCSVHCSTCEKYI--------- HroWnt5b --------CGLMC--CDRGYRSS-KVKYVERCKCKFHWCCNVSCQTCERSM--------- HroWnt6 --------CEYLC--CGRGFEKR-REIIEEECRCTFKWCCTVVCSICKRTI--------- HroWnt7 --------CRHVC--CGRGYNNQ-VVTKRKKCDCVFHWCCHVTCKECMELT--------- LgiWnt1 --------CDLMC--CGRGYKSE-TFPVKERCHCTFHWCCQVKCQVCTRLK--------- LgiWnt10 --------CETLC--CGRGYNTL-RVKRTERCHCKFFWCCYVTCKTCEYDE--------- LgiWnt11 --------CDVMC--CGRGYDSF-KMEVMERCECKYYWCCYVKCKTCVKTL--------- LgiWnt16 --------CDLLC--CGRGYNTQ-VVKYVERCHCKFFWCCYVKCKTCETMM--------- LgiWnt2 --------CDIMC--CGRGYDTK-TIVKQEQCECKFHWCCLVKCKECSKTM--------- LgiWnt4 --------CELLC--CGRGYRTR-IVTIKERCFCKFLWCCYVKCKECTRQI--------- LgiWnt5 --------CGLLC--CGRGYNTF-KRKLIERCNCKFHWCCFVRCGSCERYV--------- LgiWnt6 --------CDLLC--CGRNYSKK-QVTIKENCNCRFMWCCEVICETCQKIK--------- LgiWnt7 --------CDLMC--CGRGYNTH-QYTRTWQCNCKFHWCCYVNCNKCSERT--------- LgiWnt9 --------CETMC--CGRGYNVK-HTTVVKACKCQVFWCCHVKCKQCLKNQ--------- LgiWntA --------CRLMC--CGRGYYTL-IKEEKDDCDCKFYWCCRVECKKCTNVK--------- PduWnt1 --------CDLMC--CGRGWVEE-TYLSKERCNCTFHWCCQVTCHICNRTR--------- PduWnt10 ------------------------------------------------------------ PduWnt11 --------CRSMC--CDRGYTSH-VMEIKQRCDCKYYWCCYVKCKTCTTKV--------- PduWnt16 --------CDLLC--CGRGYNTE-VIRMVERCHCKFVWFCKVKCKICETMV--------- PduWnt2 ------------------------------------------------------------ PduWnt4 --------CELMC--CGRGYVTK-KRVIIERCHCKFHWCCYVKCQNCKREI--------- PduWnt5 --------CTLMC--CGRGYNTY-RTVVQERCQCKFHWCCYVKCKTCQREV--------- PduWnt6 --------CELMC--CGRGYIKS-LRKSLQNCQCRLVWCCQVICKTCTKVE--------- 'PduWnt7 - wnt7 CDS' --------CGMLC--CGRGYNTH-QFMRTWKCNCKFHWCCKVTCQNCSERS--------- PduWnt8 TTRWERRSCKTLCTSCGLKVSKR-MTTVQRKCDCQFHWCCEVKCKLCVEDL--------- 'PduWnt9/14/15' --------CEEI------------------------------------------------ PduWntA --------CSLMC--CGRGYYTT-VREIKEDCNCKFHWCCRVECDKCSKKI--------- PvuWnt1 --------CDLMC--CGRG----------------------------------------- PvuWnt10 --------CETLC--CGRGYNTL-RVKRTERCECKFYWCCYVMCKTCSMMN--------- PvuWnt2 --------CDIMC--CGRGFFTQ-TERKLQQCECKFHWCCLVKCKECSGLLTFIPVRELF PvuWntA --------CRLMC--CGRGHR--------------------------------------- SmaWnt1 --------CHYLC--CGRGFKRQ-TFVQQERCDCKFQWCCKVVCKTCRKTV--------- SmaWnt11 --------CVNMC--CGRGYRNV-TKREIVQCNCRMANGFKVQCDEC------------- SmaWnt11b --------CVNMC--CGRGYRNV-TKREIVQCNCRMANGFKVQCDECNVET--------- 'SmaWnt2(d)' --------CSRLC--CDSGYDTL-ELEREQKCECKFF----------------------- 'SmaWnt4(d)' --------CHYLC--CGRGFKRQ-TFVQQERCDCKFQWCCKVVCKTCRKTV--------- SmaWnt5 --------CATLC--CNRGSQTQ-LREVREKCHCQFNWCCRVECQTCVKTE--------- SmeWnt1 --------CNNLC--CNRPFLTR-SKTIMENCNCKFIWCCKVECQQCQKRI--------- SmeWnt11a --------CSNMC--CGRGYREV-MEKETVQCRCELVDVYIVKCKQCIQIN--------- SmeWnt11b --------CTNMC--CGRGHRTV-LEQKRTKCGCFIDDKFKIQCDDCYSNV--------- SmeWnt2b --------CQELC--CHRGHLTY-EMVVEENCDCKFFWCCEVRCKICRRKV--------- SmeWnt4 --------CAHLC--CKRGFSTK-QFLVKEKCQCKFVWCCTVQCQTCEILK--------- 'SmeWnt4.' --------CYRLC--CQRGYHIK-TYIKDEQCHCKFKWCCKVICETCKRKV--------- 'SmeWnt4..' --------CEELC--CGRGHKKR-TFSRVEQCHCKFHWCCDVKCDQCRKDV--------- SmeWnt5 --------CEGLC--CNRRYRTF-TREVHEKCHCKFIWCCKIKCQVCIRLE--------- SmeWntP-4 --------CNNLC--CNYGFVKV-KKLVVEQCNCKFKWCCKVECEKCEKMT--------- CteWnt1 ----------------------------------VRHICL*------------------- CteWnt10 ----------------------------------WVTVCK*------------------- CteWnt11 ----------------------------------EINRCR*------------------- CteWnt16 ----------------------------------DKQTCK*------------------- CteWnt2 ----------------------------------KVNTCRGPNPTAAPPISNSIYARRTF CteWnt4 ----------------------------------DEYVCR*------------------- CteWnt5 ----------------------------------DINTCK*------------------- CteWnt6 ----------------------------------SIHRCN*------------------- CteWnt7 ----------------------------------EEYTCK*------------------- CteWnt8 ----------------------------------ELSTCTL*------------------ CteWnt9 ----------------------------------DIYTCK*------------------- CteWntA ----------------------------------ERHICN*------------------- EgrWnt1 ----------------------------------RQETCM-------------------- EgrWnt11a ----------------------------------VRHTC--------------------- EgrWnt11b ----------------------------------LRNICK-------------------- 'EgrWnt2/10' ------------------------------------------------------------ EgrWnt4 ----------------------------------VVSTC--------------------- EgrWnt5 ----------------------------------EVHICN-------------------- 'EmuWnt1.ORF' ----------------------------------RQETCM-------------------- 'EmuWnt11.1' ----------------------------------VRHTC--------------------- 'EmuWnt11.2' ----------------------------------RRNICK-------------------- 'EmuWnt2/5/8/10.ORF' ----------------------------------GKEIVL-------------------- EmuWnt4 ----------------------------------VVSTC--------------------- EmuWnt5 ----------------------------------EVHICN-------------------- HmiWnt1 RTHRNAFITKSQAYLIQTPTPTFCIPHIMTQPYYIRHSCRLMFIRKCIYFLALNISQNTR HmiWnt11a ----------------------------------VRHTC--------------------- HmiWnt11b ----------------------------------TRNICK-------------------- HmiWnt2 ------------------------------------------------------------ HmiWnt4 ----------------------------------VVSTC--------------------- HmiWnt5 ----------------------------------EVHICN-------------------- HroWnt1 ----------------------------------ERFVCE-------------------- HroWnt10 ------------------------------------------------------------ HroWnt11a ----------------------------------EVHKCR-------------------- HroWnt11b ----------------------------------LVHF---------------------- HroWnt11C ------------------------------------------------------------ HroWnt16a ----------------------------------IKYTCK-------------------- HroWnt16b ----------------------------------VVHTC--------------------- HroWnt2 ------------------------------------------------------------ HroWnt4 ----------------------------------ELYRCK-------------------- HroWnt5a ----------------------------------DVHV---------------------- HroWnt5b ----------------------------------HVHTC--------------------- HroWnt6 ----------------------------------EVFRCL-------------------- HroWnt7 ----------------------------------EESSCR-------------------- LgiWnt1 ----------------------------------VRNTCL*------------------- LgiWnt10 ----------------------------------WVTVCK*------------------- LgiWnt11 ----------------------------------NLSKCR*------------------- LgiWnt16 ----------------------------------DIHTCK*------------------- LgiWnt2 ----------------------------------DVQTCKGPISSSASSLLSSSSLSSLQ LgiWnt4 ----------------------------------EEHTCL*------------------- LgiWnt5 ----------------------------------DVHICR*------------------- LgiWnt6 ----------------------------------TETRCL*------------------- LgiWnt7 ----------------------------------EEYTCK*------------------- LgiWnt9 ----------------------------------EIYMCK*------------------- LgiWntA ----------------------------------EMHYCN*------------------- PduWnt1 ----------------------------------VRHLCL-------------------- PduWnt10 ------------------------------------------------------------ PduWnt11 ----------------------------------EINRCR*------------------- PduWnt16 ----------------------------------DKHTCK*------------------- PduWnt2 ------------------------------------------------------------ PduWnt4 ----------------------------------EEHTCL-------------------- PduWnt5 ----------------------------------DVHTCK*------------------- PduWnt6 ----------------------------------TIYNCR*------------------- 'PduWnt7 - wnt7 CDS' ----------------------------------QIFTCK*------------------- PduWnt8 ----------------------------------ALLTCSL*------------------ 'PduWnt9/14/15' ------------------------------------------------------------ PduWntA ----------------------------------EEHFCN-------------------- PvuWnt1 ------------------------------------------------------------ PvuWnt10 ----------------------------------G------------------------- PvuWnt2 LHLRLLS---------------------------LLHLLRRKK----------------- PvuWntA ------------------------------------------------------------ SmaWnt1 ----------------------------------VISTC--------------------- SmaWnt11 ------------------------------------------------------------ SmaWnt11b ----------------------------------VTQRCL*------------------- 'SmaWnt2(d)' ------------------------------------------------------------ 'SmaWnt4(d)' ----------------------------------VISTCN*------------------- SmaWnt5 ----------------------------------EYHVCN*------------------- SmeWnt1 ----------------------------------FIETCQ*------------------- SmeWnt11a ----------------------------------IRKFCL*------------------- SmeWnt11b ----------------------------------KTFYCL*------------------- SmeWnt2b ----------------------------------FVYRCKHLE*---------------- SmeWnt4 ----------------------------------VESRCN*------------------- 'SmeWnt4.' ----------------------------------IDAICN*------------------- 'SmeWnt4..' ----------------------------------IEAVCD*------------------- SmeWnt5 ----------------------------------QVHVCN*------------------- SmeWntP-4 ----------------------------------TKFYCKIPQTSKKFHKYYLNG----- CteWnt1 ---------- CteWnt10 ---------- CteWnt11 ---------- CteWnt16 ---------- CteWnt2 T*-------- CteWnt4 ---------- CteWnt5 ---------- CteWnt6 ---------- CteWnt7 ---------- CteWnt8 ---------- CteWnt9 ---------- CteWntA ---------- EgrWnt1 ---------- EgrWnt11a ---------- EgrWnt11b ---------- 'EgrWnt2/10' ---------- EgrWnt4 ---------- EgrWnt5 ---------- 'EmuWnt1.ORF' ---------- 'EmuWnt11.1' ---------- 'EmuWnt11.2' ---------- 'EmuWnt2/5/8/10.ORF' ---------- EmuWnt4 ---------- EmuWnt5 ---------- HmiWnt1 DYETS----- HmiWnt11a ---------- HmiWnt11b ---------- HmiWnt2 ---------- HmiWnt4 ---------- HmiWnt5 ---------- HroWnt1 ---------- HroWnt10 ---------- HroWnt11a ---------- HroWnt11b ---------- HroWnt11C ---------- HroWnt16a ---------- HroWnt16b ---------- HroWnt2 ---------- HroWnt4 ---------- HroWnt5a ---------- HroWnt5b ---------- HroWnt6 ---------- HroWnt7 ---------- LgiWnt1 ---------- LgiWnt10 ---------- LgiWnt11 ---------- LgiWnt16 ---------- LgiWnt2 TVQRVLNKP* LgiWnt4 ---------- LgiWnt5 ---------- LgiWnt6 ---------- LgiWnt7 ---------- LgiWnt9 ---------- LgiWntA ---------- PduWnt1 ---------- PduWnt10 ---------- PduWnt11 ---------- PduWnt16 ---------- PduWnt2 ---------- PduWnt4 ---------- PduWnt5 ---------- PduWnt6 ---------- 'PduWnt7 - wnt7 CDS' ---------- PduWnt8 ---------- 'PduWnt9/14/15' ---------- PduWntA ---------- PvuWnt1 ---------- PvuWnt10 ---------- PvuWnt2 ---------- PvuWntA ---------- SmaWnt1 ---------- SmaWnt11 ---------- SmaWnt11b ---------- 'SmaWnt2(d)' ---------- 'SmaWnt4(d)' ---------- SmaWnt5 ---------- SmeWnt1 ---------- SmeWnt11a ---------- SmeWnt11b ---------- SmeWnt2b ---------- SmeWnt4 ---------- 'SmeWnt4.' ---------- 'SmeWnt4..' ---------- SmeWnt5 ---------- SmeWntP-4 ---------- ; end;