#NEXUS begin taxa; dimensions ntax=83; taxlabels CteWnt1 CteWnt10 CteWnt11 CteWnt16 CteWnt2 CteWnt4 CteWnt5 CteWnt6 CteWnt7 CteWnt8 CteWnt9 CteWntA EgrWnt1 EgrWnt11a EgrWnt11b EgrWnt4 EgrWnt5 EmuWnt1 EmuWnt11a EmuWnt11b EmuWnt2 EmuWnt4 EmuWnt5 HmiWnt1 HmiWnt11a HmiWnt11b HmiWnt2 HmiWnt4 HmiWnt5 HroWnt1 HroWnt10 HroWnt11a HroWnt11b HroWnt11c HroWnt16a HroWnt16b HroWnt2 HroWnt4 HroWnt5a HroWnt5b HroWnt6 HroWnt7 LgiWnt1 LgiWnt10 LgiWnt11 LgiWnt16 LgiWnt2 LgiWnt4 LgiWnt5 LgiWnt6 LgiWnt7 LgiWnt9 LgiWntA PduWnt10 PduWnt11 PduWnt16 PduWnt2 PduWnt5 PduWnt6 PduWnt7 PduWnt8 PduWnt9 PduWnt1 PduWnt4 PduWntA PvuWnt1 PvuWnt10 PvuWnt2 PvuWntA SmaWnt1 SmaWnt11a SmaWnt2 SmaWnt4 SmaWnt5 SmeWnt1 SmeWnt11a SmeWnt11b SmeWnt2 SmeWnt4a SmeWnt4b SmeWnt4c SmeWnt5 'SmeWnt?' ; end; begin characters; dimensions nchar=191; format datatype=protein missing=? gap=- interleave=yes; matrix CteWnt1 IARSCAEGSIYTCTCGRHSRRLANSVDWEWGGCSDNAEFGRKFSHDFIDVAE-KGRCLMN CteWnt10 ----------------------------VWKGCQHNVRFGDYFTRKFWGSKK-EATNEMD CteWnt11 ISKACTQGATTKCSCGRI--PNEAPP--------DDLRFGMIFSASFADSPFLKRKAMMN CteWnt16 VTKACSSGNLTDCTCDLSQQGQTS-GGWKWGGCSDNVDYGMWFAETFVDAPEKLRHSLMN CteWnt2 ITRACSQGRLTNCACDP--TKTGSSSKFDWGGCSDNVRYGSHFARMFVDAREKRVKALMN CteWnt4 VTKACSSGQVDKCGCDRSIRGKSPQ-GFEWAGCSDNVAYGSAFCGMFVDARERAKGALMN CteWnt5 VSRSCRDGQLTNCGCSRRMRPKTLHRDWLWGGCGDNTDYGYRFAQGFVDIREREKNTLMN CteWnt6 VTQACSLGLLLQCMCDNSVMDRSTDGKWEWAGCNEDVRFGSRKAAEFLDIPP-TQRGRIL CteWnt7 ITQACSQGSIMSCGCDKTKGDTSNAFEWKWGGCSADIKYGLTFSRLFLDSKE-VKEALMN CteWnt8 ITKNCSSGEFENCRCDESKKGKKGGRTWKWGGCSDNLRFGERVSKLFFDDRVA---ATVN CteWnt9 FSRACAQGRLDRCTCDESFSASKNKEAWLWGGCGDNIQYGMKFARRFLR-WMRKS-ATAD CteWntA VTTACAKGELHICDCDEKVRSQDTKGGFIWGGCSHNVAFGDRFTREFVDSNE-NRFGLMN EgrWnt1 VSEAC-LTNLRNCPCNN-RGRESFEGNWQWQGCDHNIHFGRRFGRYLLDPLEAGGFFLMN EgrWnt11a IGRYCALNFQ-------------------------------------------------- EgrWnt11b IARRCAENKIMDCECGRI--DKWNVPQYHWGGCSDNVETAKTYTQAFLGLPSENRPQKQN EgrWnt4 VTKACSSGMHDSCGCDRTIYDHERQPNFEWSGCSDNIHFGAAFSRKFLDSRERGRV---- EgrWnt5 LARSCKEARLSSCGCSKAERPQQLHRDWIWGGCGDNIDYAYRFSKAFVDIREKEKSKLMN EmuWnt1 VSEAC-LTNLRNCPCNN-RGRESFEGNWQWQGCDHNIHFGRRFGRYLLDPLEAGGFFLMN EmuWnt11a IGRYCALN---------------------------------------------------- EmuWnt11b IARRCAENKIMDCECGRI--DNWNVPQYNWGGCSDNVETAKTYTQAFLGLPLENRPRKQN EmuWnt2 ------------------------------------------LIRPF--------KTLLT EmuWnt4 VTKACSSGMHDSCGCDRTIYDHERQPNFEWSGCSDNIHFGAAFSRKFLDSREKGRV---- EmuWnt5 LARSCKEARLLSCGCSKAERPQQLHRDWIWGGCGDNIDYAYRFSKAFVDIREKEKSKLMN HmiWnt1 ISEAC-LTNIRNCPCNN-RGRESFEVNWQWQGCDHNIHYGRRFGRRLLDPLETGGFFLMN HmiWnt11a IGRYCALNKIRYCSCGMT--GGTE------------------------------------ HmiWnt11b IGRRCAENKIMDCECGRL--DNWDIPQYHWGGCSDNVEAAKTYTQAFLGFPAETRPKKRN HmiWnt2 VTRACSRGRISTCDCDVTRRGGLKAGPFTWGGCSDPIRFGMRLVRLFQEPRLPSSKTIID HmiWnt4 VTKACSSGMHDSCGCDRTIYDHERQPNFEWSGCSDNIHFGAAFSRKFLDSREKGRV---- HmiWnt5 IARSCKEARLSSCGCSKAERPQQLHRDWIWGGCGDNIDYAYRFSKAFVDLREKEKSKLMN HroWnt1 -----------------------------WDGCNDNDIFGSEFTREFIDRGE-KYRSGVL HroWnt10 ISRACSAADLQYCGCTSA-----QLR-RYSQACQSSLTYGDVMRKKFME------RRSLR HroWnt11a IAKACSSGLTSKCGCAQI--PTEPAP--------DDVKFGVAFSRQFTDQTESRRKVLMN HroWnt11b LERYCHLGRIERCRCAKR--WHESDD--------NRIRYVGKISRSFTDGSLKAIQVLTR HroWnt11c IAKTCSSGYSTKCSCGRH--PFDEPPG-------DDVRFSVDFSHKFTDK-FWQKKLMIN HroWnt16a ---------------------------WKWGGCSDDIDYGLSYAKLFT-------DPIKD HroWnt16b ITSSCSAGLLLECSCDRSVQSIVSTDSWRWGGCSDNVQYAIKYSKIITDGGNKQKDSVVH HroWnt2 VHKRCYSGKIKNCNC-----GSGGNSDAIR--CRDELAFGEKFARDFIDDNLM------R HroWnt4 VTKACSSGRLKNCGCDRTL---------EWSGCSDNVAYGKAFARSLIDVREE------N HroWnt5a VARACKDGQLHQCGCSRREKPRHLPAEWVWGGCGDNTEYGFKFGVGFVDSREREMNMLSN HroWnt5b ISRMCRDGELTGCGCSKK-------KEWIWGGCGDNTDYGYKFSGGFVDVMEK------N HroWnt6 IFEACSRGQLSQCGCEKT-----ISRPQIWRSCAGVVSFAATIAQTFTESSDFGSRSILH HroWnt7 ITRACSRSDLAGCACDK-----SVSKDWEWNGCSANVNYGIKFCENFLDAREKYSDSLMN LgiWnt1 IARACSEGSIHTCSCDFEHN-KVPVGDWEWSGCSDNARYGHKFSRRFVDVLE-KGRYMMN LgiWnt10 VSKACSMGKLKSCGCDMSVYGNQQN--FEWGGCSHNINFGAKYASKFLDSKERTSRAQIN LgiWnt11 VARACSIGVTRKCSCGAL--PNTAPT--------DDLHFGMALGRAFTDASLKSKKAMMN LgiWnt16 VTQSCSAGNLTDCSCDMSKYGRENKGGFQWGGCSDNVDYGLKFSRGFVDAPEIVRHNLMN LgiWnt2 ITSACSKGELLHCACDP--TKRGTSKEFDWGGCSDSVRFGSRFSRMFVDAKEKRVSALMN LgiWnt4 VTRACSSGTLQKCGCDRTVRGRSPE-GFEWSGCSDNIDYGMAFSKAFVDAREKGKKALMN LgiWnt5 ISRACREGELSKCGCSRARRPKDLHRDWIWGGCGDNIEYGYKFAKAFVDMREKEKNMLMN LgiWnt6 VTEACSMGRLLQCTCDNNLRDIATDGEWEWGGCGDNVDFGYQKSREFMDARRRKRRTLVQ LgiWnt7 ITQSCGLGSLPNCGCDKDKGD-GKLAGWKWGGCSADIKHGLRLARKFMDARE-IAQSLMN LgiWnt9 FARACSKGVLDRCTCDES-KHLENHKTWLWGGCGDNLRYGLKFTRKFLK-RARKSGAKVN LgiWntA VTRACAKGDLDHCGCDTKVRRISTEGEFEWGGCSDNIRYGSKFSKDFVDSKE-MRIGLMN PduWnt10 VARACSLGKLESCGCQPVLNHATNQ--WQWKGCDHNVEFGNAFGRKFLDSED-RAKSKVN PduWnt11 VSRACSIGATTKCGCGRL--PSEPPPGFKWGGCGDDLRFGLAYADLFAAPGGKGKRHLVN PduWnt16 --------------------------------------------------------SLVN PduWnt2 -------------------------------------RYGAKFSRLFIDAREKRVRALMN PduWnt5 VARSCRDGELSTCGCSRRPRPKGLHRDWIWGGCGDNSEYGYRFAEGFIDAREREKNTLMN PduWnt6 ITHACSTGQSMQCSCD--VRDRRNDGSFEWGGCSDNVRFGYQKTRDLLDVVKKGRRTLVR PduWnt7 ITQSCSSGNLTSCGCDKLGGRRPSQQDFNWGGCSVDVRYGLKFSRVFIDARE-VDESLMN PduWnt8 LTRNCSAGHIEKCSCDDSKKGTRGGANWLWGGCSDNVHFGERISRLFLDSRVTG--AIVH PduWnt9 LSRACSTHQLERCSCAPSVRGRKD--AWLWGGCDDNIQFGLRFTKRFFQ-AKALNKANID PduWnt1 VARACSEGSIFTCSCGRRRRIDVTSSTWEWGGCSDNIEFGQRFSREFVDLVE-KGRYMMN PduWnt4 VTRACSSGTMSECGCDRTVRGRSPA-GFEWAGCSDNIAFGTAFSRTFVDARERVRKVLMN PduWntA ITKACAKGDLHMCSCDTSIRNKETKGEFLWGGCSHNVKFGERFTREFVDTKE-NGEGLMN PvuWnt1 -----SEA-VFTCSCDYEHN-KVPVGDWEWSGCSDNARYGHRFSRRFVDVIE-KGRYMMN PvuWnt10 VSKACSMGKLKSCGCDMSVYGNDKN--FEWGGCSHNIEFGSRYARRFMDSKE-VAKSQIN PvuWnt2 ITRACSKGDLLHCACDP--TKRGSSKEFDWGGCSDNVRFGSHFVRMFVDAKERKVRALMN PvuWntA --------------------RTS--G-----------------SPGLQDSAR-VRLGLMN SmaWnt1 VAEAC-LNQIDNCPCNN-RGRQEPFSDWQWQGCDHNIHYGKRFSRRLLDTMERGSRFEMN SmaWnt11a IGRYCALNKIRYCSC--------------------------------------------- SmaWnt2 ITRACSRGQLGTCDCDPHRREGQR--IFTWGGCSDPIRFGMRLARLFLD-----ANTLMN SmaWnt4 VTKACSSGLHDNCGCDRTIYDHPREPNFEWSGCSDNIYFGAEFSRQFLDVRERNRLGLTN SmaWnt5 LARSCKEARLYSCGCSKADRPDQLHRDWIWGGCGDNIAYAYRFAKAFIDVREKEKSMLMN SmeWnt1 VAEACS-FKLSHCPCNN-KGR----SNWIWQGCDDNVQFGRRFARKMFDP-DIPDWTLMN SmeWnt11a ISRRCSQNKLRHCSCGKD--ESDAN-----VGCLDNIDIGIESTRNFLGFHQMGMK-RLN SmeWnt11b IARRCAQNKMAHCSCGTS--NPTAN-----QECPDNVEIGLEYVRKFTGYHKLGRKQRLN SmeWnt2 ITNSCSKGDLKECYCDPQ--RHGQDKDFTWGGCSDHIKFGMKVSTIFLDNYD----ALMN SmeWnt4a VTKACSKGVHDSCGCDRTIYDTPESERFKWSGCSHNIHFGAAFTRQFLDVPDKIRVALTK SmeWnt4b VTKACSQGVHSNCGCDRTVYDAPKDSKFTWSGCSHNIHFGAAFSRRFLDAREKIRLALTN SmeWnt4c VSKACSSGQNKYCGCDRTIYETPED-NFQWAGCSDNVHFGAAFSKRFLDSPHKRKIGLVN SmeWnt5 IARSCKEGKLSTCGCSDENRPEDLHRDWLWGGCGDNLKYAYWFAKNFIDIREKESSIMVN 'SmeWnt?' VTKACSRGDLKFCQCSADQQDLSGMNKDQLTNCNENVDYGKSFTEIFLDKRKKSRKIFLE CteWnt1 LHNSEAGRTQVSSEMSKECKCHGMSGSCTVKTCWMKLPFGRVGKVVKDRFDGASQVEQPP CteWnt10 VHNSRAGRMIWRENV-LHCKCHGMSGSCEVRTCWKAASFRKVGSIIKQKFEQATKVDTR- CteWnt11 LHNNNAGRKIISDSLVTDCKCHGVSGSCNIKTCWKAL-MRTVGTKIQERYRLAVEV--KT CteWnt16 LQNNAVGRQVINDQMNLKCRCHGVSGSCAVKTCWRTLTFREAGNELKQKYENSISIAETS CteWnt2 LQNNRAGRRAVRRHMTLECKCHGVSGACTIRTCWLALQ--RVGSYLKTRYDSAKQVSK-K CteWnt4 LHNNEAGRLAVEENMKVQCKCHGVSGSCEMKTCWRGLPFREVGAMLKDRFDGASEVEEKP CteWnt5 LHNNEAGRRAVYSHTVVACKCHGVSGSCSLKTCWNQLAFRGTGNRIKDAYDRGTEVAFNK CteWnt6 LHNNKAGRASVAKYQQKICKCHGLSGSCELKTCVLKMPFRDVGDRLKERFDGAYKVSIRP CteWnt7 LHNNRAGRKAVKSQMT-QCKCLGVSGACTIKTCWTTLPFRSIGDHLKQKFTKAKQVVR-K CteWnt8 LHNNEVGRTALKKTMELICKCHGVSGSCTTKTCWQHLSFRSVGTFLKRCYARAIDVD--- CteWnt9 SHNSDVGIRVVRNGINKTCKCHGVSGSCTVQTCWRQLAFHEVGSDLKSKYDSAVKVVN-S CteWntA LWNNNAGRKAIRTSMKLLCKCHGVSGSCSAKICWKTMTFRNIGSQLKDKFDGASRVIHKP EgrWnt1 LHNYRVGRRVVAENMQRYCRCHGTSGSCTLKTCYRRTPMRVIGNQLKVKYEQASQVMRQK EgrWnt11a ---------MMIALQKQSCKCHGVSGSCTQKVCFRQLQTEPIKAALRQRYLV-GCLQHE- EgrWnt11b SRKRKRKIQIIEGSQKIRCKCQGVSGSCAHKICFRQLLSAQLQDIILQRYMV-------- EgrWnt4 -------VQAVVKKMDIKCKCHGVSGSCEMRTCWRALPFRSVGTQLRELFQEAVMVDYPM EgrWnt5 LHNNRVGRLVSRSAHIVACKCHGMSGSCSLRTCWTQLSFPRVGQRLQERYESAIKVSSRQ EmuWnt1 LHNYRVGRRVVAENMQRYCRCHGTSGSCTLKTCYRRTPMRVIGNQLKVKYEQASQVMRQK EmuWnt11a --------------QKQSCKCHGVSGSCTQKVCFRQLQTEPIKAALRQRYLV-GCLQHE- EmuWnt11b SRKRTRKIQIIEGSQKIRCKCQGVSGSCAQKICFRQLLSAQLQNIILQRYMV-------- EmuWnt2 LLYS-PPLQFIWQSREKKCKCHGISGACTLRTCWQRVG---------------------- EmuWnt4 -------VQAVVKKMDIKCKCHGVSGSCEMRTCWRALPFRSVGTQLRELFQEAVMVDYPM EmuWnt5 LHNNRVGRLVSPSAHIVACKCHGMSGSCSLRTCWTQLSFPRVGQRLQERYESAIKVSSRQ HmiWnt1 LHNYRAGRRVVSENMQRYCRCHGTSGSCTLKTCYRRTPMRTIGNE------------GLK HmiWnt11a -------MIIMISLQKQSCKCHGVSGSCTQKVCFRQLQTEPIKAAIKQRYLA-TDFEDE- HmiWnt11b SKKKTK--RIIEDSQKIRCKCQGVSGSCAHKICFRQLLSSQLQDIILQRYMMASELAFT- HmiWnt2 VDDSRSEAAFVWQSREKKCKCHGVSGACSLRTCWQRTGPFRG----VGDLGHLGVSGR-- HmiWnt4 -------LKAVVNKMDIKCKCHGVSGSCEMRTCWRALPFRSVGNQLQDLFQKAVMVDYPM HmiWnt5 LHNNRVGRLVSSYKYTVACKCHGMSGSCSLRTCWTQLSFPRVGQRLQERYESAIRV--RQ HroWnt1 KHNSRAGRQHVLQNMQKECKCHGMSGTCSLKTCWMKMPISLVAAILKEKFNGATKVDQKP HroWnt10 QHNENLGRKLVKKMAIVRCKCHGVSGSCQLKTCWKVAPFRRVADVIKTKFKMAVRV---- HroWnt11a VDNAHVGRKMLADSIAAICKCHGVSGSSSLKTCFKSL-LKVVAVMLQNRYSAAVEM--KR HroWnt11b LHNTAVGRKIITKSLAKYCRCHGTSGSCNVKVCWMAFNINSMMIKHKNRYNNNNNISSSQ HroWnt11c LHNNRVGRQVMSTSLGTSCKCHGVSGSCSVKTCWKSLPLKTIGALLVHQYAIAVEV---- HroWnt16a LHNNEVGRQILSSLMKIKCPCHGVSGLCGVRTCWKSLRFREVAHALKNKYETSIEIS--- HroWnt16b LHNNDVGRKTFHSLMTHKCRCHGVSGSCAVRSCWRSLPFRQVGDQLKFKYLDSVEISPQP HroWnt2 MRNNAAGRRAVRKSLRLNCTCYGASGSCTVRTCWNSTAFSEIAEFLMSKYN--------- HroWnt4 LHNNNAGRKTVELSMRTHCRCHGVSGSCEMKTCWKTLPFDDVSKRLKINYDNSKMVKH-- HroWnt5a LHNNMVGRRTVVGLSKASCRCHGASGSCSMKTCWHQMAFNEIARELKFKYENLPHLVKNR HroWnt5b LHNNEVGRSEVYRHVKIGCKCHGTSGSCSVRTCWNQLPFRQTGDRLRDRYDAAAQVT-NG HroWnt6 RHNHRVGRLLSTSPTRQHCKCHGLSASCTIFTCWQKLPFATVGKKLRKVYEKAVLMTM-- HroWnt7 LHNNRPGRKVLRSSMR-NCKCSGVSGSSSVKTCWTSLHMKTIGSKLMKTYERARQVEK-K LgiWnt1 LHNNEAGRVHVSSGMKQECKCHGMSGSCTIKTCWMRLPFRNIGHILKDRFDGASKVLPRP LgiWnt10 LHNNRAGRLAIIRHVRKQCKCHGMSGSCELKTCWKAAPFRAVGTILKKKYDRATKVDII- LgiWnt11 RHNFAAGRKIVESSLTTACKCHGVSGSCSIKTCWKSL-FDSIGATLKNRYALAVEV--KK LgiWnt16 LHNNEVGRQIVEKNMQLRCRCHGVSGSCAVRTCFRSLPFRKVGLELKDKYEKSVRLARIS LgiWnt2 LHNNRAGRRAVRRFRKLMCKCHGISGSCTLRTCWLAME--RVGDFLKRKYNGATQIMK-H LgiWnt4 LHNNEAGRKAVDANMKVECKCHGVSGSCEMRTCWKAMPFKKVGEILKEKFDGATEVKHKR LgiWnt5 VHNNEAGRRAVYNFAKVACKCHGVSGSCSLKTCWQHLPFREIGNRLKDRYDASTEVKFNK LgiWnt6 LHNNEAGRQAVRKYMRKECKCHGLSGSCTLKTCWRKMPFRDVGNRLKQKFDGGSKVISPP LgiWnt7 LHNNRAGRKAVKDNMT-DCKCHGVSGSCTMKTCWTTLPFRKIGDSLKKRYKKSKIVVR-K LgiWnt9 QHNSRVGIKVVKENVNTTCKCHGVSGSCTVKTCWLQLSFSKIGRTLKNKYERAKKVLN-A LgiWntA VWNNGAGRKMVKDELELMCKCHGVSGSCSVKICWRKMKFRAIGSALKGRFDGASLVKMRP PduWnt10 RHNNKVGRMTVFENLRKMCKRHGMSGSCEMKTCWRAAPFHVVGEVLKQKYLQASKVQMIT PduWnt11 SHNNAAGRKLISDSLQTACKCHGVSGSCSIKTCWKALPLKELGMMLQKKYAIAVEVDLKV PduWnt16 LQNNQVGREAIAKQLHLRCRCHGVSGSCAVKSCWKTMPFNEVGKFLKKRYEKPTEIAPRS PduWnt2 LHNNRAGRRAVKKFMKLQCKCHGVSGSCTIRTCWLAMQFRRVGAFLKSKYNGAVQVMMNQ PduWnt5 VHNNEAGRRAVFMHSKVACKCHGVSGSCSLKTCWNQLPFREVGDRLKDKYDGATEVKFNR PduWnt6 MHNNKAGRLAVRNHVRKVCKCHGLSGSCTLETCWLKMPIHSIGRHLKQKFDGATMMFGSN PduWnt7 LHNNRAGRKALKDLMARDCKCHGVSGSCTLRTCWRTLPFRSIGASLMRRYNRARQVMPIK PduWnt8 LHNNDVGRISIRRNLKLVCKCHGVSGSCTTKTCWQQLAFKEVGIYLRRKYRRALKVDFHG PduWnt9 RHNSRVGLKVVKNGLHKTCKCHGVSGSCTTQTCWHTLSFEEIGKILKMKYRNAVRYPPGS PduWnt1 LHNNQAGRIHVVSEQHQECKCHGMSGSCTVKTCWMRLAFRQTGARLKDRFDGASRVYQSP PduWnt4 LHNNEAGRKIIEENMLTQCKCHGVSGSCELKTCWRAMPFRKIGYMLKEKFDGACEVQQKP PduWntA IWNNGAGRKTIKSSMRLLCKCYGVSGSCSVKICWRTMAFREIGRHLKQKFDGASLVTIKP PvuWnt1 LHNNEAGRVHVSTGMNQECKCHGMSGSCTIKTCWMRLPFRTVGNLLKDRFDGASRVLPRP PvuWnt10 LHNNRAGRLAVIRHVKKLCKCHGMSGSCELKTCWKAAPFRAVGAILKRKYEAATQVDIR- PvuWnt2 LHNNRAGRRAVKRFRKLECKCHGVSGSCTVRACWLAMQ--RVGDYLKLKYNGATQIMK-R PvuWntA VWNNGAGRKTVKEELDLICKCHGVSGSCSVKICWRKMKFRAIGTTLKNRFDGASLVKMRP SmaWnt1 LHNNGVGRQVVIKNMERYCRCHGTSGSCTLRTCYRRTPMRTLGTLLKHMYDHHSSILMKH SmaWnt11a ------------------CKCHGVSGSCAQRVCFRQLRTEIMQKALKMRYLA-NGFIDE- SmaWnt2 LHNKKAGRRLIWKNRITKCKCHGVSGACSMRTCWQRVNSNRINPVVSNDYSNNGRLQRRW SmaWnt4 LHNNYVGRHMVINKMEVQCKCHGVSGSCEMRTCWRSLPFRNLGAQLQERFHEAIQVTYPS SmaWnt5 LHNNRAGRLAVYKLASVACKCHGVSGSCSLRTCWTQLSFTRIGRYLRQGYDEAIKVS--R SmeWnt1 LHNTGTGRRVAVKSMNVKCVCQGTSGSCTTKICHRKVAIDEIGNILK-----------QY SmeWnt11a GHNYEVGIMIMMNSWKSKCKCHGVSGSCINKICFRQLRDEELLKMIKDYYLRTTGLQKD- SmeWnt11b GHNYEAGLRIQLDNQKIHCKCHGVSGGCNQRICYRQVRDDVLLNVLRKQYLSGSEERPD- SmeWnt2 QHNNRVGRRVVWKTRLKKCKCHGVSGACSLRTCWQRMN--RIGDMLKKLYNKPQKVTRRP SmeWnt4a LHNNHVGRQAVIMKMAKKCKCHGVSGSCEMKTCIRALPFRVVGDLLKSRFHKAMQVHF-M SmeWnt4b MHNNHVGRESVINKMIVKCKCHGVSGSCEMRTCSRNLPFRVVGDQLKERFRKIIQVDF-M SmeWnt4c LHNSHAGTKIVIDNMMMKCKCHGVSGSCETKTCYRALPLRKVGDILKEKFSKAILVRM-R SmeWnt5 LHNNNAGRMAVYKMSSVACKCHGVSGSCSLRSCWKQLPFIQIGHHMTQKYDMAKQVK--K 'SmeWnt?' LYNNHVARNVIIKSMETKCKCQGASGACTSKYCWKTLPFSKIGEALKNKYLNAKKLPRKP CteWnt1 EP-KDLVYFERSPTFCTKDPIGVEGCDLLCCGRGYRSELYTARERCNCIFHWCCKVTCDT CteWnt10 HIDNDLVYFERSPNFCEPDKLHIDSCDTLCCGRGYNTV-LTKIERCQCKFRWCCDVLCKK CteWnt11 SFSEELIYYTKSPDYCLPDGDGSIGCQSMCCGRGFTSQV-EVKHRCECKYFYCCYVECKT CteWnt16 NNGLDMVYIEDSPNYCRKNMDARDSCNTLCCGRGYNTEVVRFVERCQCKFVWCCEVKCKI CteWnt2 TTRSDIVFFDES--YCVQDPKGPHGCDVMCCGRGYDTH-VRRMRKCDCKFHWCCYVKCRE CteWnt4 HETQDLVYLEASPDYCISDPKAIDGCELMCCGRGFNVKRRVVDERCHCKFHWCCYVKCQQ CteWnt5 PTKEDLLYLAESPDYCEADPQGMDGCNLMCCGRGYNTYKAKVSERCQCKFHWCCYVQCKT CteWnt6 SG-ENLVYLDESPSFCKPSRSTTDSCDIMCCGRGYRSYKVVVQENCRCQFKWCCKVICQT CteWnt7 PRKADLVYLKRSPSYCEKDENSYNNCDLMCCGRGYNTH-YTRTWQCDCKFHWCCHVTCDE CteWnt8 ------------------------GCHRLCKACGLKVTDKVVEVTCKCKFKWCCEVACQQ CteWnt9 VQS-DLVFLEKSPNYCEPTACDLNNCDILCCGRGYNIHTRIVDKPCHCQVIWCCHVKCQR CteWntA NK-KDLVYLQESPDFCSSNTYGLDGCSLMCCGRGYQTTLITVVEDCNCKFVWCCNVVCDE EgrWnt1 PTTQELVFYEQPANFCEPNPSASDSCRLLCCERGHRTKHYYALENCECKFVWCCRVECQK EgrWnt11a ----DDPS-----------------CMNMCCGRGHKST-HQIYEKCNCIMQPNFKVHCQT EgrWnt11b --------------YCSTN----DHCQNMCCGRGYVTY-ETTFTNCNCRITRDFRVICDK EgrWnt4 LKENELIYTTRSPSYCHHDPKGPDNCNFLCCGRDYRREVFIQQEKCKCKFHWCCEVRCET EgrWnt5 ITSDHLIYLEESPNFCAVNPHANERCTVLCCGRGHRTYTREVQERCYCQFHWCCSVECQT EmuWnt1 PTTQELVFYEQPANFCEPNSSASDSCRLLCCGRGHRTKHYYALENCECKFVWCCRVECQK EmuWnt11a DDPSDLVFTQHSPDYCDPD----PGCVNMCCGRGHKST-HQIYEKCNCIMQPNFKVHCQT EmuWnt11b --------------YCSTN----DHCQNMCCGRGYVTY-ETTFTNCNCRITRDFRVICDK EmuWnt2 ------------------------------------------------------------ EmuWnt4 LKENELIYTTRSPSYCHHDPKGPDNCNFLCCGRDYRREVFIQQEKCKCKFHWCCEVRCET EmuWnt5 ITSDHLIYLEESPNFCAVNPHANERCTVLCCGRGHRTYTREVRERCYCQFHWCCSVECQT HmiWnt1 PTTKELVFYEQPTKFCNANPTGPENCNSLCCGRGYRTRHYYALENCECKFVWCCRVECQK HmiWnt11a ----DLVVTQHSPDYCDPDPTGDGRCAIMCCGRGHKST-HQIYEKCNCIMQPNFKVHCQT HmiWnt11b ---------EHSPDFCSTN----VHCQNMCCGRGHVTF-ETKFTNCNCRITKDFRVICDK HmiWnt2 --------------QCVDKPNSPNSCDKICCGRGYDIFEVDTKEKCNCKFVW-------- HmiWnt4 PKENELIYTTRSPSYCHHDPKGPDNCETLCCGRDYRREVFIQQEKCKCKFHWCCEVRCET HmiWnt5 ITPDHLIYLEDSPNFCAVNPHSSERCSHLCCGRGHRTFTREVPDRCFCQFHWCCSIECQT HroWnt1 TK-FDLVYYEDSPTFCDPDPMGMDGCDVMCCGRGYKKVTVREVQKCNCSFVWCCDVTCDY HroWnt10 ------------------------------------------------------------ HroWnt11a VASTRLVFSSISPDYCLPDPTGSSACRSMCCGRGYVSEVVQTFK-CNCKYYWCCEVKCKV HroWnt11b ESFSNLIYS---AIYCLPDKKKQGHCDVMCCGRGFRNER-SRGVKCHCKYYWCCYVKCKT HroWnt11c ------------------------------------------------------------ HroWnt16a ISSADLIFLKKSPDYCKQNLTGPDGCDYLCCGRGFNLAETRLVERCHCKFIWCCSVQCKM HroWnt16b ASDTDLIFLDKSPNYCRPDRDKPNNCKHLCCGRGYRTRVIEVDEACECQFMWCCSIQCKI HroWnt2 ------------------------------------------------------------ HroWnt4 FNETDLLFTHASPSYCDLDLATTDSCKVLCCGRGYVVVEVTLVEKCHCKFHWCCRVECQE HroWnt5a PTRDTLIYTEPSADFCEALTPGSEGCDLMCCGRGYNTFREKVTEGCRCHFVWCCSVHCST HroWnt5b PTKDDLIFTEPSPNFCNPDPQGTSGCGLMCCDRGYRSSKVKYVERCKCKFHWCCNVSCQT HroWnt6 --PRSLVYSVKNLDFCTRNVTKIGSCEYLCCGRGFEKRREIIEEECRCTFKWCCTVVCSI HroWnt7 PSYRELVYLGESPDYCKKNRDGLENCRHVCCGRGYNNQ-VTKRKKCDCVFHWCCHVTCKE LgiWnt1 GR-RDLVYFEHSPTFCEKENLGVNGCDLMCCGRGYKSETFPVKERCHCTFHWCCQVKCQV LgiWnt10 PKHLELLFYEKSPNFCDPNPGGINNCETLCCGRGYNTLRVKRTERCHCKFFWCCYVTCKT LgiWnt11 TIRSELIYYTKSPDYCSPDARGSGGCDVMCCGRGYDSFM-EVMERCECKYYWCCYVKCKT LgiWnt16 K--QELVFVHRSPNYCKEDIPTEESCDLLCCGRGYNTQVVKYVERCHCKFFWCCYVKCKT LgiWnt2 PTRSDLVYFESS--YCIKDELGTGGCDIMCCGRGYDTK-IVKQEQCECKFHWCCLVKCKE LgiWnt4 HTESDLVYMVASPDFCEADKKAIDGCELLCCGRGYRTRIVTIKERCFCKFLWCCYVKCKE LgiWnt5 YTKNDIIFLDDSPDYCDKNAQGLGGCGLLCCGRGYNTFKRKLIERCNCKFHWCCFVRCGS LgiWnt6 SK-EDLVYSEESPDFCRRNKMGVGGCDLLCCGRNYSKKQVTIKENCNCRFMWCCEVICET LgiWnt7 PRRSHLVYLDKSPNYCDFDGKDTDGCDLMCCGRGYNTH-YTRTWQCNCKFHWCCYVNCNK LgiWnt9 LNNENLLYMDESPSFCRRSRCDKDDCETMCCGRGYNVKHTTVVKACKCQVFWCCHVKCKQ LgiWntA TK-KDLVYLNESPDFCEHNLYGLDGCRLMCCGRGYYTLIKEEKDDCDCKFYWCCRVECKK PduWnt10 NSKSSLVFYETSPNFCEDSSTDIDNCETLCCGRGYNTLKVTRVERCNCRFHWCCYVVCKK PduWnt11 NQAEELIYYTKSPDYCLPDTTSSGGCRSMCCDRGYTSHVMEIKQRCDCKYYWCCYVKCKT PduWnt16 K-GDELVYLDPSPNYCRQNPKGPDSCDLLCCGRGYNTEVIRMVERCHCKFVWFCKVKCKI PduWnt2 ETRSDLVYLEDSPDYCLQDTLGPEGCDIMCCGRGYDVRTERRTEKCECKFHWCCYVQCKE PduWnt5 ATKEDLLYLSLSPDYCLANDPGMDGCTLMCCGRGYNTYRTVVQERCQCKFHWCCYVKCKT PduWnt6 DDGEDLVYTTQSPDFCRVDKKALDGCELMCCGRGYIKSLRKSLQNCQCRLVWCCQVICKT PduWnt7 GRRADLVYLRHSPNYCENDPTGTDGCGMLCCGRGYNTHQFMRTWKCNCKFHWCCKVTCQN PduWnt8 AKKGDLVYLAKSGNYCSLNGKGRRSCKTLCTSCGLKVSKRMTVPRCDCQFHWCCEVKCKL PduWnt9 HRKRDLLFLEDSINFCDSS--DRK-CEEICCGRGHNLKVRMVRK-CNCTFTWCCHATCNE PduWnt1 GP-QDLVYFEESPTFCDENRIGVDGCDLMCCGRGWVEETYLSKERCNCTFHWCCQVTCHI PduWnt4 HSSTDLVYLVASPDFCERDPKAIDGCELMCCGRGYVTKKRVIIERCHCKFHWCCYVKCQN PduWntA AK-DELVYMEDSPDYCEYDPYGLDGCSLMCCGRGYYTTVREIKEDCNCKFHWCCRVECDK PvuWnt1 GR-RDLVYFENSPTFCEKENLGVQGCDLMCCGRG-------------------------- PvuWnt10 PKHLELLFYEKSPNFCDPNPIGIDNCETLCCGRGYNTLRVKRTERCECKFYWCCYVMCKT PvuWnt2 PTRSDLVYFETS--YCIKDILGTDGCDIMCCGRGFFTQ-ERKLQQCECKFHWCCLVKCKE PvuWntA TK-KDLVYLQESPDFCEHNLYGLDGCRLMCCGRGHR------------------------ SmaWnt1 PSLSQLVYYENEKAFCDSYPSNMNNCRHLCCNRGFITHHYYIMESCHCKFIWCCRVECQQ SmaWnt11a ----ELVFSEHSPDYCNVEPTGTSNCVNMCCGRGYRNV-KREIVQCNCRMANGFKVQCDE SmaWnt2 PR-----------TYCFFDEDAINSCSRLCCDSGYDTLLE-REQKCECKFF--------- SmaWnt4 PTENDLIYISESPTFCHHDPQGLNSCHYLCCGRGFKRQTFVQQERCDCKFQWCCKVVCKT SmaWnt5 ITPDHITYLDESSNYCDYDSTDQASCATLCCNRGSQTQLREVREKCHCQFNWCCRVECQT SmeWnt1 PYARDLVYLEDVPKYCDSKPNSTDSCNNLCCNRPFLTRSKTIMENCNCKFIWCCKVECQQ SmeWnt11a -----LAFIEHSSDYCEPDPSKTNHCSNMCCGRGYREV-EKETVQCRCELVDVYIVKCKQ SmeWnt11b -----LVFTEHSPDFCEPDPTSTEHCTNMCCGRGHRTV-EQKRTKCGCFIDDKFKIQCDD SmeWnt2 SK-KKLVYIDNS--YCIQDPSQHDSCQELCCHRGHLTY-MVVEENCDCKFFWCCEVRCKI SmeWnt4a FTDNDLIYLLKSPNYCVHNPETRGSCEELCCGRGHKKRTFSRVEQCHCKFHWCCDVKCDQ SmeWnt4b FAEVDMLYLNDSPDHCHHDFEPENSCYRLCCQRGYHIKTYIKDEQCHCKFKWCCKVICET SmeWnt4c ITEHDLTYLKRSPNFCYHNPFVEGSCAHLCCKRGFSTKQFLVKEKCQCKFVWCCTVQCQT SmeWnt5 LQPDELIYYKNSPDYCELSRKKSERCEGLCCNRRYRTFTREVHEKCHCKFIWCCKIKCQV 'SmeWnt?' FIEEDLMFLRPSFDYCFPGIKGVNGCNNLCCNYGFVKVKKLVVEQCNCKFKWCCKVECEK CteWnt1 CTKTKVRHICL CteWnt10 CLMTSWVTVCK CteWnt11 CTKKVEINRCR CteWnt16 CETITDKQTCK CteWnt2 CEELVKVNTCR CteWnt4 CKKVVDEYVCR CteWnt5 CERVVDINTCK CteWnt6 CSRTLSIHRCN CteWnt7 CTELTEEYTCK CteWnt8 CRRKVELSTCT CteWnt9 CSVREDIYTCK CteWntA CIKREERHICN EgrWnt1 CLVLKRQETCM EgrWnt11a CIRNEVRHTC- EgrWnt11b CPRIVLRNICK EgrWnt4 CEKTVVVSTC- EgrWnt5 CSRREEVHICN EmuWnt1 CLVLKRQETCM EmuWnt11a CIRNEVRHTC- EmuWnt11b CPRIVRRNICK EmuWnt2 ----------- EmuWnt4 CEKTVVVSTC- EmuWnt5 CSRREEVHICN HmiWnt1 CLVLKRFET-- HmiWnt11a CIRNEVRHTC- HmiWnt11b CPQVVTRNICK HmiWnt2 ----------- HmiWnt4 CEKTVVVSTC- HmiWnt5 CIRKEEVHICN HroWnt1 CDVVEERFVCE HroWnt10 ----------- HroWnt11a CRKLVEVHKCR HroWnt11b CVQDVLVHF-- HroWnt11c ----------- HroWnt16a CERVEIKYTCK HroWnt16b CKKVQVVHTC- HroWnt2 ----------- HroWnt4 CKRRVELYRCK HroWnt5a CEKYIDVHV-- HroWnt5b CERSMHVHTC- HroWnt6 CKRTIEVFRCL HroWnt7 CMELTEESSCR LgiWnt1 CTRLKVRNTCL LgiWnt10 CEYDEWVTVCK LgiWnt11 CVKTLNLSKCR LgiWnt16 CETMMDIHTCK LgiWnt2 CSKTMDVQTCK LgiWnt4 CTRQIEEHTCL LgiWnt5 CERYVDVHICR LgiWnt6 CQKIKTETRCL LgiWnt7 CSERTEEYTCK LgiWnt9 CLKNQEIYMCK LgiWntA CTNVKEMHYCN PduWnt10 CLISDWVTVCK PduWnt11 CTTKVEINRCR PduWnt16 CETMVDKHTCK PduWnt2 CTKLVDVHTCK PduWnt5 CQREVDVHTCK PduWnt6 CTKVETIYNCR PduWnt7 CSERSQIFTCK PduWnt8 CVEDVALLTCS PduWnt9 CMVKKEMYTCK PduWnt1 CNRTRVRHLCL PduWnt4 CKREIEEHTCL PduWntA CSKKIEEHFCN PvuWnt1 ----------- PvuWnt10 CSMMNG----- PvuWnt2 CS--------- PvuWntA ----------- SmaWnt1 CLVLKKVETCI SmaWnt11a CNVETVTQRCL SmaWnt2 ----------- SmaWnt4 CRKTVVISTCN SmaWnt5 CVKTEEYHVCN SmeWnt1 CQKRIFIETCQ SmeWnt11a CIQINIRKFCL SmeWnt11b CYSNVKTFYCL SmeWnt2 CRRKVFVYRCK SmeWnt4a CRKDVIEAVCD SmeWnt4b CKRKVIDAICN SmeWnt4c CEILKVESRCN SmeWnt5 CIRLEQVHVCN 'SmeWnt?' CEKMTTKFYCK ; end;