Olson Lab

Department of Life Sciences, The Natural History Museum, London SW7 5BD United Kingdom

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Planarians to Parasitism:
A research program in the developmental biology of NTDs


Parasitic flatworms comprise a large group of extraordinarily diverse animals that includes some of the most significant Neglected Tropical Diseases of ourselves and our domesticated animals, such as bloodflukes (Schistosoma) and tapeworms (Taenia, Echinococcus). We have developed the beetle/rodent-hosted tapeworm Hymenolepis microstoma as a tractable laboratory model for studying the development, genomics and evolution of these parasites.

Planarians are free-living cousins of parasitic flatworms that have served as powerful models of regeneration and stem cell biology for well over a century. Unlike most animals, including ourselves, flatworms maintain pluripotent stem cells throughout their lives, enabling both whole-body regeneration and ‘immortal’ growth. Although free-living and parasitic animals have been studied historically in separate fields of science, contemporary knowledge demonstrates that this approach has been misguided and a hindrance to understanding the biology of both types of organisms.

Our research aims to understand parasitic flatworms in the context of their natural animal affinities and draws heavily on our understanding of the gene regulatory networks that underpin development and regeneration in planarians. In this way, our work contributes to global efforts to control and eradicate the NTDs that diminish our health and economy.

PHOTO CREDIT: Alex Gruhl


We are grateful to the Natural History Museum, BBSRC, The Wellcome Trust Sanger Institute, The Royal Society, Marshall Aid Commemoration Commission, National Science Foundation and additional funding bodies for their generous support of our work.
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RECENT PUBLICATIONS

Macchiaroli et al. 2019. Identification and expression profiling of microRNAs in Hymenolepis. International Journal for Parasitology
PUBLICATIONS

Olson PD et al. 2018. Genome-wide transcriptome profiling and spatial expression analyses identify signals and switches of development in tapeworms. BMC EvoDevo
PUBLICATIONS

International Helminth Genomes Consortium. 2018. Comparative genomics of the major parasitic worms. Nature Genetics
PUBLICATIONS

NEWS

NGS_COVER_FRONT

Available Now! Next Generation Systematics 2016. PD Olson, J Hughes and JA Cotton (ed.). Cambridge University Press
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